Proteolytic Disassembly of Viral Outer Capsid Proteins Is Crucial for Reovirus-Mediated Type-I Interferon Induction in Both Reovirus-Susceptible and Reovirus-Refractory Tumor Cells

<div>Reovirus-mediated induction of IFN-<i>β</i> and Noxa in tumor cells. (a), (b) Dose-dependent induction of IFN-<i>β</i> and Noxa expression by reovirus. qRT-PCR analysis was used to measure mRNA levels of IFN-<i>β</i> and Noxa 24 hrs after infection. The data were normalized by the data of the mock group. The data shown represent the mean ± SD of triplicate measurements.</div>

BioMed Research International

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Figure 1

Figure 1: Proteolytic Disassembly of Viral Outer Capsid Proteins Is Crucial for Reovirus-Mediated Type-I Interferon Induction in Both Reovirus-Susceptible and Reovirus-Refractory Tumor Cells 

Figure 1 | Proteolytic Disassembly of Viral Outer Capsid Proteins Is Crucial for Reovirus-Mediated Type-I Interferon Induction in Both Reovirus-Susceptible and Reovirus-Refractory Tumor Cells 