BioMed Research International

BioMed Research International / 2015 / Article

Comment on “Transmission Model of Hepatitis B Virus with the Migration Effect”

  • Abid Ali Lashari |
  •  Article ID 469240 |
  •  Published 30 Aug 2015

Comment on “Transmission Model of Hepatitis B Virus with Migration Effect”

  • Anwar Zeb | Gul Zaman |
  •  Article ID 492513 |
  •  Published 17 Dec 2015
  • | View Article

Letter to the Editor | Open Access

Volume 2015 |Article ID 469240 | 2 pages |

Comment on “Transmission Model of Hepatitis B Virus with the Migration Effect”

Academic Editor: Kanury V. S. Rao
Received14 Feb 2015
Accepted18 Aug 2015
Published30 Aug 2015


Some consequences of erroneous results concerning eigenvalues in the recent literature of mathematical biology are highlighted. Furthermore, an improved stability criterion and the true value of the basic reproduction number is presented.

1. Introduction

Stability analysis of a mathematical model describing the dynamics of a problem in biology requires a knowledge of the eigenvalues of the Jacobian matrix associated with the matrix [1]. The Routh-Hurwitz criteria give necessary and sufficient conditions for the eigenvalues to lie in the left half of the complex plane. However, recent literature in mathematical biology contains instances of authors establishing stability of the Jacobian matrix by using erroneous results concerning eigenvalues of a matrix. One of the results is stated below.(1)Eigenvalues of a matrix are invariant under elementary row [or column] operations. See, for example, Khan et al.’s Theorems 1 and 2.

2. Falseness of the Above Statement

The example occurs in the proof of Theorems 1 and 2 of Khan et al. [2]. The theorem states the following:(1) For , the disease-free equilibrium of the system (3) about an equilibrium point is locally asymptotically stable if ; otherwise, the disease-free equilibrium of system (3) is unstable for .(2) For , the endemic equilibrium of system (3) is locally asymptotically stable, if the following conditions hold:otherwise, the system is unstable.

In order to prove these results, they performed elementary row operation for the Jacobian matrix (9) at the disease-free equilibrium and obtained matrix (10) (similarly, by elementary row operation for the Jacobian matrix (14) at and obtaining the matrix (15)). Then, they analyse matrices (10) and (15) obtained after elementary row transformation from (9) and (14), respectively, to show that all the eigenvalues of (9) and (14) are negative from which they concluded the above assertions of their theorem. This reasoning would have been valid if elementary row transformation preserved eigenvalues, which, however, does not as shown below.

The eigenvalues for matrices (9) and (10) (similarly of matrices (14) and (15)) in [2] are not the same as they violate the well known criteria that the sum of the eigenvalues of a matrix is the same as the trace of that matrix. Now, the difference of the traces of matrices (9) and (10) is By the same reasoning, it can be easily seen that the difference of the traces of matrices (14) and (15) is also not zero. The eigenvalues would have been the same if the difference between the trace of the original and the trace of the matrix obtained after row transformation equals zero, which, however, does not. Clearly, the eigenvalues may change after an elementary row transformation. The above statement may hold in special cases but is false in general.

Moreover, the true value of the basic reproduction number of system (3), which measures the average number of new infections generated by a single infected individual in a completely susceptible population, is given by Now, we will show that the local stability of the disease-free equilibrium is completely determined by and present an improved stability result below.

Theorem 1. The disease-free equilibrium of model (3) in [2] is locally asymptotically stable if and unstable if .

Proof. The characteristic equation of the Jacobian matrix (9) in [2] is given bywhereTwo of the roots of the characteristic equation (4), and , have negative real parts. The other three roots can be determined from the cubic term in (4). Using (5), direct calculations shows thatThe term under brace is greater than zero if . Hence, . Thus, by Routh-Hurwitz criteria, the DFE of system (3) in [2] is locally asymptotically stable about the point if . Therefore, the extra condition is not required and the local stability of the disease-free equilibrium is completely determined by .

3. Conclusion

This paper has pointed out some technical problems in the results in [2] and has presented the corrected version of the corresponding result and the true value of the basic reproduction number. Studies of mathematical models of the spread of hepatitis B virus have great impact on health authorities’ planning and allocation of funds to control the spread of infectious diseases. The effective control decisions of the disease have an important role in the combat of the disease and will be very useful for the public as well as the funding agencies. However such resources are likely to go to waste if scientific studies which purport to guide them are based on faulty theoretical basis. The conclusion based on the model proposed by Khan et al. [2] may not be valid and hepatitis B may still be far from reaching its equilibrium from the community. A wrong mathematical result published in a respectable journal, if left unchallenged, is usually accepted by young research workers as gospel. It is likely to corrupt the scientific literature with growing speed in a manner like the spreading of an infectious disease.

Conflict of Interests

The author declares that there is no conflict of interests regarding the publication of this paper.


  1. L. Cai, A. A. Lashari, I. H. Jung, K. O. Okosun, and Y. I. Seo, “Mathematical analysis of a malaria model with partial immunity to re-infection,” Abstract and Applied Analysis, vol. 2013, Article ID 405258, 17 pages, 2013. View at: Publisher Site | Google Scholar
  2. M. A. Khan, S. Islam, M. Arif, and Z. Ul Haq, “Transmission model of hepatitis B virus with the migration effect,” BioMed Research International, vol. 2013, Article ID 150681, 10 pages, 2013. View at: Publisher Site | Google Scholar

Copyright © 2015 Abid Ali Lashari. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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