Isotypes of Epstein-Barr Virus Antibodies in Rheumatoid Arthritis: Association with Rheumatoid Factors and Citrulline-Dependent Antibodies

Figure 2

Scattergrams showing individual levels of EBNA-1 IgG/IgM/IgA in plasma from RA patients, SLE patients, and HCs and individual levels of EBNA-1 IgG/IgM/IgA from RA patients divided into CCP IgG positives and negatives and divided into IgA RF and IgM RF positives and negatives. (a) EBNA-1 IgM/IgG/IgA levels. RA patients (), SLE patients (), and HCs (). (b) EBNA-1 IgM/IgG/IgA levels sorted into CCP IgG positives () and CCP IgG negatives (). RA patients total (). (c) EBNA-1 IgA levels sorted in IgA RF states, IgA RF positives () and IgA RF negatives (). EBNA-1 IgG levels sorted in RF states, IgM or IgA RF positives () and RF negatives (). EBNA-1 IgM levels sorted in IgM RF states, IgM RF positives () and IgM RF negatives (). RA patients total (). Groups were compared using the Mann-Whitney test. Data are presented as mean ± SEM. Concentrations of antibodies are presented in arbitrary units. Statistical significant differences are indicated with , , , or for values less than 0.05, 0.01, 0.001, or 0.0001, respectively.

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