Resource Review
A Large-Scale Structural Classification of Antimicrobial Peptides
Table 4
Top 10 common AMP structural folds annotated by CATH and SCOP.
| | AMP structural folds | CATH | SCOP | | Fold cluster ID | Class | Architecture | Topology | Class | Fold |
| | 1 | Alpha beta | 2-layer sandwich | Defensin A-like | Small proteins | Knottins |
| | 2 | Mainly beta | Beta barrel | OB fold | Alpha and beta proteins (a + b) | IL8-like |
| | 3 | Mainly alpha | Up-down bundle | Single alpha-helices involved in coiled-coils or other helix-helix interfaces | Peptides | Antimicrobial helix |
| | 3 | — | — | — | Peptides | Liposaccharide-binding protein CAP18 |
| | 3 | — | — | — | Peptides | Peptide hormones |
| | 4 | Alpha beta | Roll | Antimicrobial peptide, beta-defensin 2; chain A | Small proteins | Defensin-like |
| | 5 | — | — | — | Small proteins | Knottins |
| | 6 | Mainly alpha | Orthogonal bundle | Histone, subunit A | All alpha proteins | Histone-fold |
| | 7 | Mainly alpha | Orthogonal bundle | Lysozyme | Alpha and beta proteins (a + b) | Lysozyme-like |
| | 8 | Alpha beta | 2-layer sandwich | Crambin | Small proteins | Crambin-like |
| | 9 | Mainly alpha | Orthogonal bundle | NK-lysin | All alpha proteins | Saposin-like |
| | 9 | Mainly alpha | Up-down bundle | Bacteriocin As-48; chain A | All alpha proteins | Saposin-like |
| | 10 | Alpha beta | Roll | P-30 protein | Alpha and beta proteins (a + b) | RNase A-like |
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