Anesthesia Related Toxic Effects on In Vitro Fertilization Outcome: Burden of Proof

Table 2

Details of trials investigating general anesthesia’s (GA’s) potential toxicity.

First author/year	GA versus other techniques	Sample size	Pregnancy rates	Fertilization rate	Oocytes
Aghaamoo et al. 2014 [2]	GA versus spinal analgesia	164 total; GA group (); Spinal group ()	Practicing spinal anesthesia is significantly related to increased chance of chemical pregnancy ()	—	—
Azmude et al. 2013 [1]	GA versus spinal anesthesia	200 total; GA group (); Spinal group ()	Spinal anesthesia increased significantly the chance of IVF success ()	—	—
Wilhelm et al. 2002 [6]	GA versus monitored anesthesia care (MAC) with remifentanil	251 total; GA group (); MAC group ()	MAC had a greater pregnancy rate; ()	NS	NS
Hammadeh et al. 1999 [8]	GA versus sedation	202 total; GA group (); Sedation group ()	NS	NS	The number of collected oocytes was significantly higher with GA ()
Christiaens et al. 1998 [7]	GA versus paracervical local anesthetic block (PCB)	202 total; GA group (); PCB group ()	NS	NS	NS

NS: no significant difference, —: not under investigation.