BioMed Research International / 2015 / Article / Tab 1

Research Article

Melanoma Cells Homing to the Brain: An In Vitro Model

Table 1

Differentially expressed genes in M1 and M2 cells as obtained by the metastasis specific real time PCR-based array (see materials and methods, Section 2). Data are expressed as fold decrease (a) or increase (b) in M2 compared to M1.

SymbolGene nameFoldFunction

(a)
SYKSpleen tyrosine kinase−91.72AM
MCAMMelanoma cell adhesion molecule−29.76AM
VEGFAVascular endothelial growth factor A−7.85AM
CTNNA1Catenin (cadherin-associated protein), alpha 1−6.51AM
ITGB3Integrin, beta 3−6.46AM
FAT1FAT atypical cadherin 1−5.36AM
HPSEHeparanase−5.05EMD
CD44CD44 molecule−5.05AM
TIMP2Metallopeptidase inhibitor 2−4.72EMD
COL4A2Collagen, type IV, alpha 2−4.60EMD
APCAdenomatous polyposis coli−4.02AM
PNN pininDesmosome associated protein−3.53AM
MMP3Matrix metallopeptidase 3 (stromelysin 1, progelatinase)−2.58EMD
MTSS1Metastasis suppressor 1−2.57AM

(b)
CDH1Cadherin 1, type 1, E-cadherin533AM
MMP2Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase)54.35EMD
ITGA7Integrin, alpha 715.54AM
CDH6Cadherin 6, type 2, K-cadherin (fetal kidney)8.23AM
MMP10Matrix metallopeptidase 10 (stromelysin 2)6.83EMD
TIMP3TIMP metallopeptidase inhibitor 34.92EMD
CDH11Cadherin 11, type 2, OB-cadherin (osteoblast)3.97AM
MMP9matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase)3.58EMD
MMP11Matrix metallopeptidase 11 (stromelysin 3)3.55EMD
MMP13Matrix metallopeptidase 13 (collagenase 3)3.31EMD
MMP7Matrix metallopeptidase 7 (matrilysin, uterine)2.61EMD
MGAT5Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylglucosaminyltransferase2.22AM
FN1Fibronectin 12.08AM
CTSL1Cathepsin L2.06EMD