Research Article

Oxygen Transport in a Three-Dimensional Microvascular Network Incorporated with Early Tumour Growth and Preexisting Vessel Cooption: Numerical Simulation Study

Table 3

Parameter values used in the simulation.

ParameterValueDescriptionReference

10 μmLattice constant
0.82Average osmotic reflection coefficient for plasma proteinsBaxter and Jain (1989) [19]
20 mmHgColloid osmotic pressure of plasmaBaxter and Jain (1989) [19]
15 mmHgColloid osmotic pressure of interstitial fluidBaxter and Jain (1989) [19]
4.13 × 10−8 cm2/mmHg s Hydraulic conductivity coefficient of the interstitiumBaxter and Jain (1989) [19]
/200 cm−1Surface area per unit volume for transport in the interstitiumBaxter and Jain (1989) [19]
10−9 cm2s−1MDE diffusion coefficientAnderson (2005) [14]
1.3 × 102 cm3M−1s−1ECM degradation coefficientCai et al. (2011) [17]
1.7 × 10−18 Mcells−1s−1MDE production by TCCai et al. (2011) [17]
0.3 × 10−18 Mcells−1s−1MDE production by ECCai et al. (2011) [17]
1.7 × 10−8 s−1MDE decay coefficientAnderson (2005) [14]
1.27 × 10−15μmol/(μm3mmHg)Bunsen solubility coefficientFang et al. (2008) [20]
10−5 cm2s−1Oxygen diffusion coefficientAnderson (2005) [14]
6.25 × 10−17 Mcells−1s−1Oxygen consumption coefficientAnderson (2005) [14]
2.8 × 10−7 cm/mmHg s Vessel permeability in tumour tissueBaxter and Jain (1989) [19]
6.5 mmHgVessel compliance coefficientNetti et al. (1996) [21]
0.1Vessel compliance indexNetti et al. (1996) [21]