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BioMed Research International
Volume 2015, Article ID 483150, 16 pages
Research Article

Identification of Novel Potential Vaccine Candidates against Tuberculosis Based on Reverse Vaccinology

Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional (IPN), Prolongación de Carpio y Plan de Ayala S/N, Colonia Santo Tomás, 11340 México, DF, Mexico

Received 27 September 2014; Accepted 7 January 2015

Academic Editor: Tao Huang

Copyright © 2015 Gloria P. Monterrubio-López et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Results emitted by NERVE after the M. tuberculosis H37Rv proteome analysis. NERVE selected 331 proteins out of 3989 proteins of M. tuberculosis H37Rv proteome. The selection of vaccine candidates was based on the analysis of several important properties: ≥50% of adhesion probability, fewer than two transmembrane regions, no protein similarity to human proteome, not membrane or cytoplasmic localization. Conserved values are also shown, comparing each candidate against M. bovis and BCG proteomes. Finally, NERVE search and obtain a putative function for each protein.

  1. Supplementary Material