Research Article

Identification of Novel Potential Vaccine Candidates against Tuberculosis Based on Reverse Vaccinology

Table 1

Proteins selected after reducing parameters and grouped in seven categories according their family group.

Protein family groupIDRvVaxiJen antigenicity valueLength (amino acid)Psi BLAST

ESX family gi_15608177_ref_NP_215553_1_Rv1037c0.744494ND
gi_15608338_ref_NP_215714_1_Rv11980.628694ND
gi_15610755_ref_NP_218136_1_Rv3619c0.744494ND

PPE family gi_57116729_ref_YP_177724_1_Rv0388c (PPE9)0.5334180ND
gi_57116916_ref_YP_177840_1_Rv1801 (PPE29)0.5636423ND
gi_57116975_ref_YP_177871_1_Rv2353c (PPE39)0.897354ND
gi_57117024_ref_YP_177677_1_Rv2770c (PPE44)0.5056382ND
gi_57117062_ref_YP_177932_1_Rv3125c (PPE49)0.5581391ND
gi_57117064_ref_YP_177934_1_Rv3135 (PPE50)0.5029132ND
gi_57117135_ref_YP_177998_1_Rv3621c (PPE65)0.5241413ND

PE family gi_57116715_ref_YP_177710_1_Rv0285 (PE5)0.6696102ND
gi_57116910_ref_YP_177834_1_Rv1788 (PE18)0.622899ND
gi_57116913_ref_YP_177837_1_Rv1791 (PE19)0.612594ND
gi_57116998_ref_YP_177888_1_Rv2519 (PE26)0.718492ND
gi_57117110_ref_YP_177975_1_Rv3477 (PE31)0.532598ND
gi_57117136_ref_YP_177999_1_Rv3622c (PE32)0.509999ND
gi_57117151_ref_YP_178010_1_Rv3739c (PE67)0.510177ND
gi_57117167_ref_YP_178025_1_Rv3893c (PE36)0.597177ND

PE_PGRS family gi_57116752_ref_YP_177736_1_Rv0532 (PE_PGRS6)1.789594ND
gi_57116773_ref_YP_177750_1_Rv0746 (PE-PGRS9)1.7153783ND
gi_57116787_ref_YP_177759_1_Rv0832 (PE_PGRS12)0.6034137ND
gi_57116793_ref_YP_177763_1_Rv0872 (PE_PGRS15)2.0866606ND
gi_57116818_ref_YP_177780_1_Rv1067c (PE_PGRS19)2.2481667ND
gi_57116826_ref_YP_177786_1_Rv1091 (PE_PGRS22)2.5016853ND
gi_57116864_ref_YP_177811_1_Rv1441c (PE_PGRS26)2.1299491ND
gi_57116905_ref_YP_177831_1_Rv1795c (wag22)2.0054914ND
gi_57116924_ref_YP_177847_1_Rv1840c (PE_PGRS34)1.5912515ND
gi_57116973_ref_YP_177869_1_Rv2340c (PE_PGRS39)1.0512413ND
gi_57117010_ref_YP_177896_1_Rv2634c (PE_PGRS46)2.146778ND
gi_57117029_ref_YP_177909_1_Rv2853 (PE_PGRS48)2.1046615ND
gi_57117093_ref_YP_177961_1_Rv3344c (PE_PGRS49)3.0927484ND
gi_57117098_ref_YP_177965_1_Rv3367 (PE_PGRS51)2.0713588ND
gi_57117101_ref_YP_177968_1_Rv3388 (PE_PGRS52)2.2486731ND
gi_57117117_ref_YP_177981_1_Rv3512 (PE_PGRS56)3.48811079ND

Lipoproteinsgi_15607723_ref_NP_215097_1_Rv0583c (LpqN)0.6569228ND
gi_15608368_ref_NP_215744_1_Rv1228 (LpqX)0.7609185ND
gi_15608679_ref_NP_216057_1_Rv1541c (LprI)0.5298197ND
gi_15609407_ref_NP_216786_1_Rv2270 (LppN)0.5899175ND
gi_15609921_ref_NP_217300_1_Rv2784c (LppU)0.685171ND

Hypotheticsgi_15607199_ref_NP_214571_1_Rv00570.6907173No matches
gi_57116831_ref_YP_177639_1_Rv1116A0.633791Related with PE family proteins of Mycobacterium
gi_15608277_ref_NP_215653_1_Rv1137c0.76122No matches
gi_15608941_ref_NP_216320_1_Rv1804c0.575108Related with Mycobacterium lipoproteins and gp53 Mycobacterium phage
gi_15609051_ref_NP_216430_1_Rv1914c0.5202135No matches
gi_15609215_ref_NP_216594_1_Rv20780.5425104No matches
gi_15609220_ref_NP_216599_1_Rv20830.8189314No matches
gi_15609401_ref_NP_216780_1_Rv2264c0.5862592Related with proline and threonine rich Mycobacterium proteins, like chaperone molecular and Rhodococcus hypothetical proteins
gi_15609420_ref_NP_216799_1_Rv22830.733664No matches
gi_15609429_ref_NP_216808_1_Rv2292c0.539674No matches
gi_15609439_ref_NP_216818_1_Rv23020.95880Related with transduction signal protein and hypothetical proteins from Nocardia and Frankia, DNA binding protein from Streptomyces
gi_15609797_ref_NP_217176_1_Rv2660c0.907375No matches
gi_15609843_ref_NP_217222_1_Rv2706c0.52785No matches
gi_15610097_ref_NP_217476_1_Rv2960c0.694582No matches
gi_15610135_ref_NP_217514_1_Rv29980.8339153No matches
gi_15610204_ref_NP_217583_1_Rv30670.566136No matches
gi_15610316_ref_NP_217696_1_Rv3180c0.5182144Related with proteins which have pilT domain and with DNA binding proteins from Mycobacterium
gi_15610343_ref_NP_217723_1_Rv3207c0.6281285Related with membrane proteins and lipoproteins from Corynebacterium and Streptomyces
gi_57117091_ref_NP_217854_2_Rv33370.8824128Related with a putative hydrolase from Mycobacterium
gi_15610854_ref_NP_218235_1_Rv3718c0.7971147Related with KanY, polyketide cyclases, and lipid transport proteins from different species
gi_15611034_ref_NP_218415_1_Rv3898c0.7675110no matches

Othersgi_15607173_ref_NP_214545_1_Rv00310.73870ND
gi_57116685_ref_YP_177687_1_Rv0050 (PBP1)0.6113678ND
gi_57116889_ref_NP_216091_2_Rv15750.7415166ND
gi_57117071_ref_YP_177941_1_Rv3198A 0.666984ND
gi_15610488_ref_NP_217869_1_Rv3352c 0.8742123ND
gi_15610946_ref_NP_218327_1_Rv3810 (Erp)0.6734284ND
gi_15609895_ref_NP_217274_1_Rv2758c 0.657488ND
gi_57117060_ref_YP_177930_1_Rv31180.833100ND
gi_15610417_ref_NP_217798_1_Rv32810.7311177ND
gi_15611001_ref_NP_218382_1_Rv38650.604103ND
gi_15609778_ref_NP_217157_1_Rv2641 0.7934152ND
gi_15607954_ref_NP_215329_1_Rv0814c0.833100ND
gi_57116926_ref_YP_177849_1_Rv1860 0.5244325ND

Note: in bold are the highlighted representative proteins selected. ND: not determined.