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BioMed Research International
Volume 2015, Article ID 484537, 5 pages
http://dx.doi.org/10.1155/2015/484537
Review Article

Constitutive NF-κB Activation Underlines Major Mechanism of Drug Resistance in Relapsed Refractory Diffuse Large B Cell Lymphoma

Department of Lymphoma/Myeloma, MD Anderson Cancer Center, Unit 429, 1515 Holcombe Boulevard, Houston, TX 77030, USA

Received 29 May 2014; Accepted 25 September 2014

Academic Editor: Maurizio Zangari

Copyright © 2015 Francesco Turturro. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Siegel, J. Ma, Z. Zou, and A. Jemal, “Cancer statistics, 2014,” CA: A Cancer Journal for Clinicians, vol. 64, no. 1, pp. 9–29, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. R. I. Fisher, E. R. Gaynor, S. Dahlberg et al., “Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma,” The New England Journal of Medicine, vol. 328, no. 14, pp. 1002–1006, 1993. View at Publisher · View at Google Scholar · View at Scopus
  3. W. H. Wilson, M. L. Grossbard, S. Pittaluga et al., “Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy,” Blood, vol. 99, no. 8, pp. 2685–2693, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Coiffier, E. Lepage, J. Brière et al., “Chop chemotherapy plus rituximab compared with chop alone in elderly patients with diffuse large-B-cell lymphoma,” The New England Journal of Medicine, vol. 346, no. 4, pp. 235–242, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Coiffier, C. Thieblemont, E. van den Neste et al., “Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte,” Blood, vol. 116, no. 12, pp. 2040–2045, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Pfreundschuh, E. Kuhnt, L. Trümper et al., “CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group,” The Lancet Oncology, vol. 12, no. 11, pp. 1013–1022, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. A. A. Alizadeh, M. B. Elsen, R. E. Davis et al., “Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling,” Nature, vol. 403, no. 6769, pp. 503–511, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Roschewski, L. M. Staudt, and W. H. Wilson, “Diffuse large B-cell lymphoma—treatment approaches in the molecular era,” Nature Reviews Clinical Oncology, vol. 11, no. 1, pp. 12–23, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Fu, D. D. Weisenburger, W. W. L. Choi et al., “Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma,” Journal of Clinical Oncology, vol. 26, no. 28, pp. 4587–4594, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. W. H. Wilson, K. Dunleavy, S. Pittaluga et al., “Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkers,” Journal of Clinical Oncology, vol. 26, no. 16, pp. 2717–2724, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. W. H. Wilson, S.-H. Jung, P. Porcu et al., “A cancer and Leukemia Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B-cell lymphoma with analysis of outcome by molecular subtype,” Haematologica, vol. 97, no. 5, pp. 758–765, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Gisselbrecht, B. Glass, N. Mounier et al., “Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era,” Journal of Clinical Oncology, vol. 28, no. 27, pp. 4184–4190, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. R. L. Elstrom, P. Martin, K. Ostrow et al., “Response to second-line therapy defines the potential for cure in patients with recurrent diffuse large B-cell lymphoma: implications for the development of novel therapeutic strategies,” Clinical Lymphoma, Myeloma and Leukemia, vol. 10, no. 3, pp. 192–196, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. S. J. Nagle, K. Woo, S. J. Schuster et al., “Outcomes of patients with relapsed/refractory diffuse large B-cell lymphoma with progression of lymphoma after autologous stem cell transplantation in the rituximab era,” American Journal of Hematology, vol. 88, no. 10, pp. 890–894, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Nagel, M. Vincendeau, A. C. Eitelhuber, and D. Krappmann, “Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies,” Oncogene, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. L. T. Lam, R. E. Davis, J. Pierce et al., “Small molecule inhibitors of IκB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling,” Clinical Cancer Research, vol. 11, no. 1, pp. 28–40, 2005. View at Google Scholar · View at Scopus
  17. Y. Yang, A. L. Shaffer III, N. C. T. Emre et al., “Exploiting synthetic lethality for the therapy of ABC diffuse large B cell Lymphoma,” Cancer Cell, vol. 21, no. 6, pp. 723–737, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Compagno, W. K. Lim, A. Grunn et al., “Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma,” Nature, vol. 459, no. 7247, pp. 717–721, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. V. N. Ngo, R. M. Young, R. Schmitz et al., “Oncogenically active MYD88 mutations in human lymphoma,” Nature, vol. 470, no. 7332, pp. 115–121, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Bohers, S. Mareschal, A. Bouzelfen et al., “Targetable activating mutations are very frequent in GCB and ABC diffuse large B-cell lymphoma,” Genes Chromosomes and Cancer, vol. 53, no. 2, pp. 144–153, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Odqvist, S. Montes-Moreno, R. E. Sánchez-Pacheco et al., “NFκB expression is a feature of both activated B-cell-like and germinal center B-cell-like subtypes of diffuse large B-cell lymphoma,” Modern Pathology, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Taskinen, R. Louhimo, S. Koivula et al., “Deregulation of COMMD1 is associated with poor prognosis in diffuse large B-cell lymphoma,” PLoS ONE, vol. 9, no. 3, Article ID e91031, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Bartuzi, M. H. Hofker, and B. van de Sluis, “Tuning NF-κB activity: a touch of COMMD proteins,” Biochimica et Biophysica Acta—Molecular Basis of Disease, vol. 1832, no. 12, pp. 2315–2321, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. A. J. A. Deutsch, B. Rinner, K. Wenzl et al., “NR4A1-mediated apoptosis suppresses lymphomagenesis and is associated with a favorable cancer-specific survival in patients with aggressive B-cell lymphomas,” Blood, vol. 123, no. 15, pp. 2367–2377, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Harant and I. J. D. Lindley, “Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-κB,” Nucleic Acids Research, vol. 32, no. 17, pp. 5280–5290, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Montes-Moreno, L. Odqvist, J. A. Diaz-Perez et al., “EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-κB activation,” Modern Pathology, vol. 25, no. 7, pp. 968–982, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Y. Ok, L. Li, Z. Y. Xu-Monette et al., “Prevalence and clinical implications of Epstein-Barr virus infection in de Novo diffuse large B-cell lymphoma in western countries,” Clinical Cancer Research, vol. 20, no. 9, pp. 2338–2349, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. M. C. Cox, A. Di Napoli, S. Scarpino et al., “Clinicopathologic characterization of diffuse-large-B-cell lymphoma with an associated serum monoclonal IgM component,” PLoS ONE, vol. 9, no. 4, Article ID e93903, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Ruminy, P. Etancelin, L. Couronné et al., “The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma,” Leukemia, vol. 25, no. 4, pp. 681–688, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Jardin, M. H. Delfau-Larue, T. J. Molina et al., “Immunoglobulin heavy chain/light chain pair measurement is associated with survival in diffuse large B-cell lymphoma,” Leukemia & Lymphoma, vol. 54, no. 9, pp. 1898–1907, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. A. R. Mato, T. Feldman, and A. Goy, “Proteasome inhibition and combination therapy for non-Hodgkin's lymphoma: from bench to bedside,” The Oncologist, vol. 17, no. 5, pp. 694–707, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Ruan, P. Martin, R. R. Furman et al., “Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma,” Journal of Clinical Oncology, vol. 29, no. 6, pp. 690–697, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. N. Mounier, V. Ribrag, C. Haioun et al., “Efficacy and toxicity of two schedules of R-CHOP plus bortezomib in front-line B lymphoma patients. A randomized phase II trial from the Groupe d'Etude des Lymphomes de l'Adulte (GELA),” Journal of Clinical Oncology, vol. 25, no. 18, supplement, Abs 8010, 2007. View at Google Scholar
  34. K. Doner, I. W. Flinn, and B. K. Ulrich, “Rapid prospective identification of non-germinal center B cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) patients for targeted trials: Early results from PYRAMID, a phase 2 randomized study of R-CHOP +/- bortezomib in newly diagnosed non-GCB DLBCL,” Blood, vol. 116, 2010, Abstract number 1792. View at Google Scholar
  35. A. M. Evens, S. T. Rosen, I. Helenowski et al., “A phase I/II trial of bortezomib combined concurrently with gemcitabine for relapsed or refractory DLBCL and peripheral T-cell lymphomas,” British Journal of Haematology, vol. 163, no. 1, pp. 55–61, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. E. Kupperman, E. C. Lee, Y. Cao et al., “Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer,” Cancer Research, vol. 70, no. 5, pp. 1970–1980, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Assouline, J. E. Chang, B. D. Cheson et al., “Results of a Phase 1 dose-escalation study of once-weekly MLN9708, an investigational proteasome inhibitor, in patients with relapsed/refractory lymphoma,” Blood, vol. 120, Abs 3646, 2012. View at Google Scholar
  38. L.-H. Zhang, J. Kosek, M. Wang, C. Heise, P. H. Schafer, and R. Chopra, “Lenalidomide efficacy in activated B-cell-like subtype diffuse large B-cell lymphoma is dependent upon IRF4 and cereblon expression,” British Journal of Haematology, vol. 160, no. 4, pp. 487–502, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. P. H. Wiernik, I. S. Lossos, J. M. Tuscano et al., “Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma,” Journal of Clinical Oncology, vol. 26, no. 30, pp. 4952–4957, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. V. Ivanov, D. Coso, B. Chetaille et al., “Efficacy and safety of lenalinomide combined with rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma,” Leukemia & Lymphoma, 2014. View at Publisher · View at Google Scholar
  41. M. Wang, N. Fowler, N. Wagner-Bartak et al., “Oral lenalidomide with rituximab in relapsed or refractory diffuse large cell, follicular and transformed lymphoma: a phase II clinical trial,” Leukemia, vol. 27, no. 9, pp. 1902–1909, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. A. R. Jazirehi, S. Huerta-Yepez, G. Cheng, and B. Bonavida, “Rituximab (chimeric anti-CD20 monoclonal antibody) inhibits the constitutive nuclear factor-κB signaling pathway in non-Hodgkin's lymphoma B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis,” Cancer Research, vol. 65, no. 1, pp. 264–276, 2005. View at Google Scholar · View at Scopus
  43. T. Ahmadi, E. A. Chong, A. Gordon et al., “Combined lenalidomide, low-dose dexamethasone, and rituximab achieves durable responses in rituximab-resistant indolent and mantle cell lymphomas,” Cancer, vol. 120, no. 2, pp. 222–228, 2014. View at Publisher · View at Google Scholar · View at Scopus
  44. E. Van Den Neste, C. Gisselbrecht, N. Schmitz et al., “Diffuse large B-cell lymphoma (DLBCL) patients failing second-line R-DHAP or R-ICE chemotherapy included in the Coral Study,” Blood, vol. 122, no. 21, 2013, Abs 764. View at Google Scholar
  45. S. Barton, E. A. Hawkes, A. Wotherspoon, and D. Cunningham, “Are we ready to stratify treatment for diffuse large B-cell lymphoma using molecular hallmarks?” Oncologist, vol. 17, no. 12, pp. 1562–1573, 2012. View at Publisher · View at Google Scholar · View at Scopus