Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy

Figure 9

(a) (A) P-gp interacts with substrates in the plasma membrane and digoxin (substrate) is effluxed from the lipid bi-layer. (B) Cellular uptake of digoxin facilitated by Immunoliposomes-targeted to transferrin receptor and taken up via receptor-mediated endocytosis [94] (reproduced with permission from Drug Targeting Ltd. 2002). (b) (A) 2D Schematic representation of a dendrimer. (B) 3D representation of a dendrimer [100] (reproduced with permission from Elsevier B.V. Ltd. © 2009).

(a)

(b)