Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy

Table 1

The net uptake of bioactive by the brain depends on the difference between the influx and efflux processes [38] (reproduced with permission from Elsevier B.V. Ltd. © 2002).

Blood lumen	Endothelial cell	Extracellular fluid
(i) Blood Systemic exposure
(ii) Drug blood cell and protein binding	(i) Drug permeability
	(ii) Drug metabolism	Drug disposition