Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model

Figure 4

The immunohistochemical study of PI3K/phospho-PI3K expression (western blot). Upper panel: the groups are stated similar to that of Figure 3. The assay showed the reduced phosphorylation of PI3K in the SAH groups when compared with the control group. Arctigenin dose-dependently induced the expression of activated PI3D signaling when compared with the SAH groups. Data in the figure are presented as mean ± SD. (^☆, compared with the SAH group; , ^#,##,###, indicates comparison among the 75/150/450 μM/kg Arctigenin and SAH + vehicle groups, resp.).