Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model
Table 1
Physiological parameters among the experimental groups.
Group
Parameter
Body weight (gm)
Systolic Blood pressure
GOT/GPT (IU/L)
BUN/Cr (mg/dL)
pH
Temperature (°C)
Sham
374 ± 24
104 ± 12
9.2 ± 3.1/7.1 ± 2.8
4.0 ± 2.3/0.23 ± 0.14
7.36 ± 0.04
36.5 ± 0.33
SAH
360 ± 31
111 ± 8
10.2 ± 4.0/11.2 ± 3.0
9.4 ± 1.3/0.55 ± 0.14
7.37 ± 0.10
36.1 ± 0.41
SAH + Vehicle
359 ± 46
102 ± 12
12.4 ± 4.0/10.6 ± 3.8
10.2 ± 3.5/0.48 ± 0.16
7.38 ± 0.15
36.6 ± 0.42
SAH + Arctigenin
50 M/kg/day
366 ± 49
108 ± 13
10.8 ± 4.2/13.4 ± 4.8
10.4 ± 4.3/0.88 ± 0.35
7.36 ± 0.14
36.8 ± 0.32
150 M/kg/day
368 ± 36
100 ± 12
12.6 ± 3.8/7.8 ± 4.2
11.6 ± 4.1/1.3 ± 0.38
7.36 ± 0.41
36.6 ± 0.51
450 M/kg/day
370 ± 42
94 ± 34
13.5 ± 2.6/7.8 ± 3.8
12.4 ± 2.6/0.86 ± 0.43
7.38 ± 0.13
36.7 ± 0.13
Results are expressed as the mean ± SEM, = 9; versus SAH condition by one-way analysis of variance (ANOVA) analyses followed by Mann-Whitney -test.