Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder

Figure 15

Repeated exposure to WIRS causes morphological alterations in oligodendrocytes in the CC. (a) Representative transverse electron micrographs of the CC from control (upper panel of (a)) and repeated WIRS-exposed mice (lower panels of (a)). Scale bar = 2 μm. (b) Results of the quantification of the sum of oligodendrocytes in the cross-sectional area. The results are expressed as the mean ± SEM of 3 independent experiments. , -test. (c, d) The distributions of the axon diameters (c) and myelin thicknesses (d) of the CC in the control and repeated WIRS-exposed mice were assessed. The results are expressed as the mean ± SEM of 3 independent experiments. , -test. (a)–(d) are adapted with permission from Miyata et al. [37].

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