Review Article

Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder

Figure 16

Activation of the SGK1-NDRG1 pathway also causes morphological changes in primary cultured oligodendrocytes. (a) Morphology of primary cultured oligodendrocytes treated with (+DEX) ((a) right column) or without DEX (−DEX) for 2 days. (b) Overexpression of the constitutively active form of SGK1 (CA-SGK1) or kinase inactive form of SGK1 (KI-SGK1). (a, b) Morphometric measurements of oligodendrocyte diameters were performed using ImageJ software. The results are expressed as the mean ± SEM of 3 independent experiments. , -test. (a) and (b) are adapted with permission from Miyata et al. [37].
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