Biological and Pharmacological Aspects of the NK1-Receptor

Figure 1

Schematic model of the NK-1 receptor. (a) Complete isoform or long isoform-full length (NK1-FL) with 407 amino acids. It contains an extracellular N-terminus, seven transmembrane domains, three extracellular loops (E1, E2, and E3) and three intracellular loops (C1, C2, and C3), a possible C4 because of a Cys palmitoylation residue and an intracellular C-terminus. Asn14 and Asn18 are given as putative glycosylation sites. (b) Depiction of the truncated isoform with 311 amino acids, showing that this isoform has lost a part of the C-terminal end, and also the intracellular Ser/Thr residues responsible for internalization. Modified from [149].

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