miR-126 Is Involved in Vascular Remodeling under Laminar Shear Stress

Figure 6

Representative network of miR-126 in HUVECs submitted to LSS. LSS induces at short-term the expression of transcription factor, KLF-2, and at long-term miR-126 expression. miR-126 downregulates the endothelial adhesion molecule VCAM-1 and chemokine SDF-1/CXCL12. Loss of VCAM-1 and SDF-1/CXCL12 can be associated with decrease of leukocyte homing over the endothelium. miR-126 overexpression enhanced the SDC-4 which can induce the transduction pathway leading to remodeling of F-actin cytoskeleton and favors cell adhesion and spreading. VCAM-1: vascular cell adhesion molecule-1; miR-126: small noncoding micro-RNA-126; SDF-1/CXCL12: stromal cell-derived factor-1; KLF-2: Krüppel-like factor-2; SDC-4: syndecan-4.