Clinical Study

Phase II, Open Label, Randomized Comparative Trial of Ondansetron Alone versus the Combination of Ondansetron and Aprepitant for the Prevention of Nausea and Vomiting in Patients with Hematologic Malignancies Receiving Regimens Containing High-Dose Cytarabine

Table 4

Proportion of patients requiring rescue medications from day 1 to day 6.

Use of rescue medicationsOndansetron; Arm 1
Number (%)
Ondansetron + aprepitant; Arm 2
Number (%)

Day 14 (9)3 (7)0.52
Day 29 (21)3 (7)0.06
Day 37 (16)2 (5)0.07
Day 46 (14)8 (19)0.34
Day 58 (20)5 (12)0.30
Day 68 (19)4 (10)0.18