Univariate analysis of clinical and volumetric tumor data and histological and molecular parameters with tumor recurrence in patients with insular LGGs.
Factor
Tumor recurrence
HR
95% CI
Age (modelled as continuous variable)
1.009
0.973–1.047
0.608
Sex
Male
1
Female
1.368
0.595–3.415
0.460
Tumor site
Left
1
Right
0.886
0.359–2.183
0.792
Preoperative T2 tumor volume cm3 (modelled as continuous variable)
1.005
0.994–1.016
0.399
Tumor subtype
Fibrillary astrocytoma
1
Oligoastrocytoma
0.509
0.195–1.324
0.166
Oligodendroglioma
0.081
0.011–0.643
0.017
% EOR (modelled as continuous variable)
0.932
0.899–0.965
0.000
% EOR
≥90
1
70–89
2.792
0.938–7.931
0.052
≤69
8.936
2.302–34.687
0.002
ΔVT2T1 (modelled as continuous variable)
1.045
1.022–1.068
0.000
ΔVT2T1
<30 cm3
1
≥30 cm3
2.950
1.243–7.001
0.014
Mib1-Ki-67 (modelled as continuous variable)
0.931
0.722–1.201
0.585
1p/19q codeletion Presence versus absence
0.288
0.082–1.003
0.051
P53 mutation (modelled as continuous variable)
1.006
0.994–1.018
0.317
EGFR (modelled as continuous variable)
0.995
0.983–1.008
0.946
GFAP (modelled as continuous variable)
1.007
0.993–1.021
0.323
IDH1 Mutation versus no mutation
0.383
0.168–0.872
0.022
MGMT Promoter methylation versus no promoter methylation
0.912
0.375–2.215
0.840
HR, hazard ratio; CI, confidence interval; EOR, extent of surgical resection; ΔVT2T1, volumetric difference between preoperative tumor volumes on T2- and T1-weighted MRI images. Boldfacing represents statistical significance values () obtained from two-sided tests (Cox regression).
