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BioMed Research International
Volume 2015 (2015), Article ID 501262, 15 pages
http://dx.doi.org/10.1155/2015/501262
Research Article

Identification of Subtype Specific miRNA-mRNA Functional Regulatory Modules in Matched miRNA-mRNA Expression Data: Multiple Myeloma as a Case

1College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin 150081, China
2Department of Mathematics, Heilongjiang Institute of Technology, Harbin 150050, China

Received 17 July 2014; Revised 19 October 2014; Accepted 27 October 2014

Academic Editor: Lei Chen

Copyright © 2015 Yunpeng Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1. Schematic representation of a co-module. The expression values of miRNAs and mRNAs were indicated by a color code ranging from green (under-expressed) to red (over-expressed). Note that in this co-module, two samples of t(4;14) exhibited similar profiles, whereas the sample of t(14;16) exhibited an inverse profile.

Figure S2. Distribution of the number of MFRMs extracted from each co-module.

Table S1. 72 MM associated genes from OMIM, CGP and GAD.

Table S2. 63 MM associated GO biological processes.

Table S3. The top 15 miRNAs and 50 mRNAs frequently included in each kind of subtype specific MFRM.

  1. Supplementary Material