Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 504208, 7 pages
http://dx.doi.org/10.1155/2015/504208
Clinical Study

Disorders of MicroRNAs in Peripheral Blood Mononuclear Cells: As Novel Biomarkers of Ankylosing Spondylitis and Provocative Therapeutic Targets

1Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, China
2Shanghai GenePharma Co., Ltd, Shanghai 200000, China

Received 6 July 2014; Revised 13 September 2014; Accepted 14 September 2014

Academic Editor: James C. C. Wei

Copyright © 2015 Qing Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. P. Thomas and M. A. Brown, “Genetics and genomics of ankylosing spondylitis,” Immunological Reviews, vol. 233, no. 1, pp. 162–180, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. M. A. Brown, L. G. Kennedy, A. J. MacGregor et al., “Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment,” Arthritis and Rheumatism, vol. 40, no. 10, pp. 1823–1828, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. M. F. Caffrey and D. C. James, “Human lymphocyte antigen association in ankylosing spondylitis,” Nature, vol. 242, no. 5393, p. 121, 1973. View at Publisher · View at Google Scholar · View at Scopus
  4. D. A. Brewerton, F. D. Hart, A. Nicholls, M. Caffrey, D. C. O. James, and R. D. Sturrock, “Ankylosing spondylitis and HL-A 27,” The Lancet, vol. 301, no. 7809, pp. 904–907, 1973. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Schlosstein, P. I. Terasaki, R. Bluestone, and C. M. Pearson, “High association of an HL-A antigen, W27, with ankylosing spondylitis,” The New England Journal of Medicine, vol. 288, no. 14, pp. 704–706, 1973. View at Publisher · View at Google Scholar · View at Scopus
  6. M. A. Brown, L. G. Kennedy, C. Darke et al., “The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis,” Arthritis & Rheumatology, vol. 41, no. 3, pp. 460–465, 1998. View at Google Scholar
  7. V. Ambros, “MicroRNAs: tiny regulators with great potential,” Cell, vol. 107, no. 7, pp. 823–826, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. B. P. Lewis, C. B. Burge, and D. P. Bartel, “Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets,” Cell, vol. 120, no. 1, pp. 15–20, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Huang, X. J. Shen, Q. Zou, S. P. Wang, S. M. Tang, and G. Z. Zhang, “Biological functions of microRNAs: a review,” Journal of Physiology and Biochemistry, vol. 67, no. 1, pp. 129–139, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Murata, H. Yoshitomi, S. Tanida et al., “Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis,” Arthritis Research and Therapy, vol. 12, no. 3, article R86, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Tang, X. Luo, H. Cui et al., “MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins,” Arthritis and Rheumatism, vol. 60, no. 4, pp. 1065–1075, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. G. V. Glinsky, “An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway,” Cell Cycle, vol. 7, no. 16, pp. 2570–2583, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. C.-H. Huang, J. C.-C. Wei, W.-C. Chang et al., “Higher expression of whole blood microRNA-21 in patients with ankylosing spondylitis associated with programmed cell death 4 mRNA expression and collagen cross-linked C-telopeptide concentration,” Journal of Rheumatology, vol. 41, no. 6, pp. 1104–1111, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Garrett, T. Jenkinson, L. G. Kennedy, H. Whitelock, P. Gaisford, and A. Calin, “A new approach to defining disease status in ankylosing spondylitis: the bath ankylosing spondylitis disease activity index,” Journal of Rheumatology, vol. 21, no. 12, pp. 2286–2291, 1994. View at Google Scholar · View at Scopus
  15. R. C. Lee, R. L. Feinbaum, and V. Ambros, “The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14,” Cell, vol. 75, no. 5, pp. 843–854, 1993. View at Publisher · View at Google Scholar · View at Scopus
  16. D. P. Bartel, “MicroRNAs: genomics, biogenesis, mechanism, and function,” Cell, vol. 116, no. 2, pp. 281–297, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. E. van Rooij and E. N. Olson, “MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets,” Journal of Clinical Investigation, vol. 117, no. 9, pp. 2369–2376, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. P. S. Mitchell, R. K. Parkin, E. M. Kroh et al., “Circulating microRNAs as stable blood-based markers for cancer detection,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 30, pp. 10513–10518, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Chen, Y. Ba, L. Ma et al., “Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases,” Cell Research, vol. 18, no. 10, pp. 997–1006, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Wang, S. Zhang, B. Marzolf et al., “Circulating microRNAs, potential biomarkers for drug-induced liver injury,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 11, pp. 4402–4407, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. X. Ji, R. Takahashi, Y. Hiura, G. Hirokawa, Y. Fukushima, and N. Iwai, “Plasma miR-208 as a biomarker of myocardial injury,” Clinical Chemistry, vol. 55, no. 11, pp. 1944–1949, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. W. Zhu, W. Qin, U. Atasoy, and E. R. Sauter, “Circulating microRNAs in breast cancer and healthy subjects,” BMC Research Notes, vol. 2, article 89, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. H. M. Heneghan, N. Miller, A. J. Lowery, K. J. Sweeney, and M. J. Kerin, “MicroRNAs as novel biomarkers for breast cancer,” Journal of Oncology, vol. 2009, Article ID 950201, 7 pages, 2009. View at Publisher · View at Google Scholar
  24. V. N. Kim and J.-W. Nam, “Genomics of microRNA,” Trends in Genetics, vol. 22, no. 3, pp. 165–173, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Ogawa, M. Iizuka, Y. Sekiya, K. Yoshizato, K. Ikeda, and N. Kawada, “Suppression of type I collagen production by microRNA-29b in cultured human stellate cells,” Biochemical and Biophysical Research Communications, vol. 391, no. 1, pp. 316–321, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. E. van Rooij, L. B. Sutherland, J. E. Thatcher et al., “Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 35, pp. 13027–13032, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. I. K. Oglesby, I. M. Bray, S. H. Chotirmall et al., “miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression,” Journal of Immunology, vol. 184, no. 4, pp. 1702–1709, 2010. View at Publisher · View at Google Scholar · View at Scopus