Mathematical Model of Innate and Adaptive Immunity of Sepsis: A Modeling and Simulation Study of Infectious Disease

Table 1

Definition of parameters and experimental values in Kupffer Cell local response model.

Parameters	Description	Value	References
	Salmonella growth rate	1.2–3.6/h	[20]
	Salmonella carrying capacity	cells/g liver	[32]
	Rate at which pathogens are killed by Kupffer Cells	0.03/per Kupffer Cell/h	[31]
	The extent of ligands binding to receptors (not specified)	2	Estimated
	Concentration of Kupffer Cells which phagocytose half of Salmonella	0.03	[31]
	Proliferation rate of Kupffer Cells under inflammation	0.015–2/h	Estimated
	Kupffer Cell carrying capacity in liver		[40]
	Unbinding rate of binding Kupffer Cells	0.1–0.77/h	[33]
	Killing rate of free Kupffer Cells induced by binding to pathogens	0.23–0.9/h	[33]