BioMed Research International / 2015 / Article / Tab 2

Review Article

Systematic Review of the Use of Phytochemicals for Management of Pain in Cancer Therapy

Table 2

Overview of the 7 full-text articles and associated phytochemicals included in this systematic review.

StudyStudy designStudy durationPhytochemicalDeliveryPatientsCountryMajor study design bias

Bao et al. [21]124RCT, open labelImmediate interventionXiaozheng Zhitong PasteOintmentMultiple cancers with metastasesChinaControl is not a placebo

Belcaro et al. [22]80RCT, open label60 daysMeriva (lecithin delivery system of curcumin)OralChemo/radiotherapy postsurgical and multiple cancersItalyHeterogeneous cancer study population

Brooker et al. [23]66RCT, blinded12 monthsIH636 grape seed proanthocyanidin extractOralPain after high-dose radiotherapy for early breast cancerUKNone

Costa Fortes et al. [24]56RCT, blinded6 monthsAgaricus silvaticus fungus extractOralPostsurgical patients with colorectal cancer and painBrazilIntegrity of double-blinding unclear

Pawar et al. [27]27RCT, blinded50 daysSAMITAL (three botanical extracts)Oral solutionPain from oral mucositis in patients treated for neck/head cancerIndiaControl versus exposure group inequity

Pommier et al. [25]254RCT, open label6 weeksCalendula (plant)OintmentPain after radiotherapy for breast carcinomaFranceIntegrity of blinding questionable

Tröger et al. [26]220RCT, open label12 monthsMistletoeS/C injectionsPancreatic cancerSerbiaNot blinded


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