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BioMed Research International
Volume 2015, Article ID 508071, 7 pages
http://dx.doi.org/10.1155/2015/508071
Research Article

Effects of Mentha suaveolens Essential Oil on Chlamydia trachomatis

1Department of Public Health and Infectious Diseases, “Sapienza” University, Piazzale Aldo Moro 5, 00185 Rome, Italy
2Department of Drugs Chemistry and Technology, “Sapienza” University, Piazzale Aldo Moro 5, 00185 Rome, Italy

Received 30 July 2014; Accepted 13 October 2014

Academic Editor: György Schneider

Copyright © 2015 Rosa Sessa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chlamydia trachomatis, the most common cause of sexually transmitted bacterial infection worldwide, has a unique biphasic developmental cycle alternating between the infectious elementary body and the replicative reticulate body. C. trachomatis is responsible for severe reproductive complications including pelvic inflammatory disease, ectopic pregnancy, and obstructive infertility. The aim of our study was to evaluate whether Mentha suaveolens essential oil (EOMS) can be considered as a promising candidate for preventing C. trachomatis infection. Specifically, we investigated the in vitro effects of EOMS towards C. trachomatis analysing the different phases of chlamydial developmental cycle. Our results demonstrated that EOMS was effective towards C. trachomatis, whereby it not only inactivated infectious elementary bodies but also inhibited chlamydial replication. Our study also revealed the effectiveness of EOMS, in combination with erythromycin, towards C. trachomatis with a substantial reduction in the minimum effect dose of antibiotic. In conclusion, EOMS treatment may represent a preventative strategy since it may reduce C. trachomatis transmission in the population and, thereby, reduce the number of new chlamydial infections and risk of developing of severe sequelae.