S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease

Figure 5

Effect of pentamidine (0.05–5 g/mL/day) on GFAP and p53 expression in astrocyte in the hippocampi of A-injected mice. (a) Immunofluorescence analysis of hippocampal coronal sections. Note the increased GFAP expression in hippocampal astrocytes of A-treated (2) compared to vehicle-treated mice (1) and the dose-dependent reduction after pentamidine treatment (3-4-5). Scale bar: 50 m. (b) Relative quantification of p53-positive/GFAP-positive (open bars) and p53-positive/GFAP-positive (filled bars) astrocytes in the CA1 area of the brain. Results are expressed as mean ± SEM of experiments performed in triplicate. versus vehicle-treated mice; and versus A-treated mice. versus vehicle-treated mice; , versus A-treated mice.

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