Research Article
Osteopontin Involves Cisplatin Resistance and Poor Prognosis in Oral Squamous Cell Carcinoma
Table 1
Correlation between expression of OPN and clinicopathological factors of stage IVa/b OSCC.
| | | Number of patients | OPN | | Multivariates analysis | | | | Negative expression | Positive expression | OR (95% CI) |
| | Age | | | | | | | | 60 | 102 (84.3%) | 22 (21.6%) | 80 (78.4%) | 0.764 | | | | 60 | 19 (15.7%) | 5 (26.3%) | 14 (73.7%) | | | | Gender | | | | | | | | Male | 117 (96.7%) | 24 (20.5%) | 93 (79.5%) | 0.034 | 1 | | | Female | 4 (3.3%) | 3 (75%) | 1 (25%) | 0.067 (0.06–0.791) | 0.032 | | Grade | | | | | | | | Well | 77 (63.6%) | 17 (22.1%) | 60 (77.9%) | | | | | Moderate | 40 (33.1%) | 10 (25%) | 30 (75%) | 0.517 | | | | Poor | 4 (3.3%) | 0 (0%) | 4 (100%) | | | | | Stage | | | | | | | | Iva | 35 (28.9%) | 12 (34.3%) | 23 (65.7%) | 0.044 | 1 | | | IVb | 86 (71.1%) | 15 (17.4%) | 71 (82.6%) | 2.755 (1.042–7.279) | 0.041 | | T stage | | | | | | | | 1/2 | 28 (10.5%) | 5 (17.9%) | 23 (82.1%) | 0.612 | | | | 3/4 | 93 (89.5%) | 22 (23.7%) | 71 (76.3%) | | | | N stage | | | | | | | | Negative | 40 (21.1%) | 14 (35.0%) | 26 (65.0%) | 0.019 | 1 | | | Positive | 81 (78.9%) | 13 (16.0%) | 68 (84.0%) | 3.534 (1.363–9.164) | 0.009 | | Alcohol drinking | | | | | | | | Never | 30 (24.8%) | 7 (23.3%) | 23 (76.3%) | 0.877 | | | | Yes | 91 (75.2%) | 20 (22.0%) | 71 (78.0%) | | | | Smoking | | | | | | | | Never | 29 (24.0%) | 11 (37.9%) | 18 (62.1%) | 0.021 | | | | Yes | 92 (76.0%) | 16 (17.4%) | 76 (82.6%) | | | | Betel nuts | | | | | | | | Never | 31 (25.6%) | 10 (32.3%) | 21 (67.7%) | 0.123 | | | | Yes | 90 (74.4%) | 17 (18.9%) | 73 (81.1%) | | |
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OR, odds ratio; CI, confidence interval.
Indicates significantly difference ().
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