|
Gene | Variation | Official description | Trait/effect | Species | Reference |
|
NRF2 | Deletion | — | Subfertility | Mice | [7] |
rs6721961 G>T | NC_000002.11:g.178130037 T>G | Oligoasthenozoospermia | Human | [20] |
rs35652124T>C | NC_000002.11:g.178130073 T>C | Oligoasthenozoospermia | Human | [20] |
rs6721961 G>T + smoking | NC_000002.11:g.178130037 T>G | Sperm concentration and count | Human | [12] |
|
GST | GSTM1-null | Deletion | Male infertility, oligozoospermia, male infertility with varicocele | Human | [21–28] |
GSTT1-null | Deletion | Male infertility, male infertility with varicocele | Human | [24, 26–32] |
GSTM1 rs135955605 C/G | — | Sperm motility after cryopreservation | Bulls | [33] |
GSTP1 (Ile105Val) | NC_000011.10:g.67585218 A>G | Male infertility, oligospermia, oligoasthenoteratozoospermia, azoospermia | Human | [26, 31, 34] |
GSTP1 (Ala114Val) | NC_000011.10:g.67586108 C>T | Male infertility with varicocele, oligoasthenoteratozoospermia | Human | [27, 34] |
GSTM1-null + PAH exposure | Deletion | PAH-DNA adducts | Human | [35] |
GSTM1-null/GSTT1-null + smoking | Deletion | Idiopathic male infertility | Human | [36] |
GSTM1-null + CYP1A1 | Deletion | Male infertility | Human | [37] |
|
SOD | SOD2 rs4880 CC | NC_000006.11:g.160113872 A>G | Idiopathic infertility, male infertility, pregnancy rates in IVF, sperm concentration, sperm motility, and sperm DNA fragmentation | Human | [38–41] |
SOD1 knockout | — | Male infertility | Drosophila | [42] |
SOD1 knockout | — | Spermatogenic cell damage during heat stress | Mice | [43] |
|
CAT | C-262T | NC_000011.10:g.34438684 C>T | Idiopathic male infertility | Human | [44] |
|
NOS | eNOS T786C | NC_000007.13:g.150690079 C>T | Male infertility, oligoasthenoteratozoospermia, idiopathic male infertility | Human | [45–47] |
eNOS G894T | NC_000007.13:g.150696111 T>G, NP_001153582.1:p.Asp298Glu, | Oligoasthenoteratozoospermia, asthenozoospermia, idiopathic male infertility | Human | [46–50] |
eNOS 4a/b | NC_000007.14:g.150997188_150997214-AGGGGTGAGGAAGTCTAGACCTGCTGC2)3) | Idiopathic male infertility, sperm morphology | Human | [45, 47, 51] |
|
GPX | GPX4 deletion | — | Male infertility, sperm chromatin condensation | Mice | [52, 53] |
GPX5 deletion | — | Sperm DNA integrity | Mice | [54] |
|