The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method

Figure 2

Morphological changes of liver in MGCD0103 treated group at low (a), medium (b), high (c) dosage and control group (d) (hematoxylin-eosin staining, ×200). In low dose, liver cells were arranged in funicular along with central veins and became slightly edematous (a). In middle dose, the structure of liver lobule disappeared with extensive fatty changes in the liver cells (b). In high dose, a plenty of liver cells with steatosis and small, atrophy, hyperchromatic karyopyknosis and some dark blue fragment of nucleus in lobule appeared (c).

(a)

(b)

(c)

(d)