Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 518643, 5 pages
http://dx.doi.org/10.1155/2015/518643
Research Article

Analysis of Single Nucleotide Polymorphisms within ADAM12 and Risk of Knee Osteoarthritis in a Chinese Han Population

Department of Orthopaedics, The Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Road, Da Lian, China

Received 20 June 2014; Revised 24 September 2014; Accepted 27 September 2014

Academic Editor: Shigeru Kotake

Copyright © 2015 Lin Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Samuels, S. Krasnokutsky, and S. B. Abramson, “Osteoarthritis: a tale of three tissues,” Bulletin of the NYU Hospital for Joint Diseases, vol. 66, no. 3, pp. 244–250, 2008. View at Google Scholar · View at Scopus
  2. W. Zhang, M. Doherty, N. Arden et al., “EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT),” Annals of the Rheumatic Diseases, vol. 64, no. 5, pp. 669–681, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. W. Zhang, R. W. Moskowitz, G. Nuki et al., “OARSI recommendations for the management of hip and knee osteoarthritis, part II: OARSI evidence-based, expert consensus guidelines,” Osteoarthritis and Cartilage, vol. 16, no. 2, pp. 137–162, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. W. Zhang, R. W. Moskowitz, G. Nuki et al., “OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence,” Osteoarthritis and Cartilage, vol. 15, no. 9, pp. 981–1000, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. W. Zhang, G. Nuki, R. W. Moskowitz et al., “OARSI recommendations for the management of hip and knee osteoarthritis. Part III: changes in evidence following systematic cumulative update of research published through January 2009,” Osteoarthritis and Cartilage, vol. 18, no. 4, pp. 476–499, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. K. M. Jordan, N. K. Arden, M. Doherty et al., “EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT),” Annals of the Rheumatic Diseases, vol. 62, no. 12, pp. 1145–1155, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. A. M. Valdes, D. J. Hart, K. A. Jones et al., “Association study of candidate genes for the prevalence and progression of knee osteoarthritis,” Arthritis & Rheumatism, vol. 50, no. 8, pp. 2497–2507, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. K. L. Limer, K. Tosh, S. R. Bujac et al., “Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study),” Osteoarthritis and Cartilage, vol. 17, no. 6, pp. 782–789, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. S. Lou, Z. Zhao, J. Qian, K. Zhao, and R. Wang, “Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population,” International Journal of Clinical and Experimental Pathology, vol. 7, pp. 5154–5159, 2014. View at Google Scholar
  10. A. Okada, S. Mochizuki, T. Yatabe et al., “ADAM-12 (Meltrin α) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage,” Arthritis & Rheumatism, vol. 58, no. 3, pp. 778–789, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. I. Kerna, K. Kisand, P. Laitinen et al., “Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers,” Rheumatology International, vol. 32, no. 2, pp. 519–523, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. A. M. Valdes, M. Doherty, and T. D. Spector, “The additive effect of individual genes in predicting risk of knee osteoarthritis,” Annals of the Rheumatic Diseases, vol. 67, no. 1, pp. 124–127, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. M.-H. Shin, S.-J. Lee, S.-J. Kee et al., “Genetic association analysis of GDF5 and ADAM12 for knee osteoarthritis,” Joint Bone Spine, vol. 79, no. 5, pp. 488–491, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. I. Meulenbelt, “Osteoarthritis year 2011 in review: genetics,” Osteoarthritis and Cartilage, vol. 20, no. 3, pp. 218–222, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. H. Takahashi, M. Nakajima, K. Ozaki, T. Tanaka, N. Kamatani, and S. Ikegawa, “Prediction model for knee osteoarthritis based on genetic and clinical information,” Arthritis Research and Therapy, vol. 12, no. 5, article R187, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. A. M. Valdes, M. van Oene, D. J. Hart et al., “Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women,” Arthritis & Rheumatism, vol. 54, no. 2, pp. 533–539, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. I. Kerna, K. Kisand, A. E. Tamm, M. Lintrop, K. Veske, and A. O. Tamm, “Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort,” Osteoarthritis and Cartilage, vol. 17, no. 8, pp. 1093–1098, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. T. Aigner, S. Soeder, and J. Haag, “IL-1β and BMPS—interactive players of cartilage matrix degradation and regeneration,” European Cells & Materials, vol. 12, pp. 49–56, 2006. View at Google Scholar · View at Scopus
  19. B. J. Gilpin, F. Loechel, M.-G. Mattei, E. Engvall, R. Albrechtsen, and U. M. Wewer, “A novel secreted form of human ADAM 12 (meltrin α) provokes myogenesis in vivo,” Journal of Biological Chemistry, vol. 273, no. 1, pp. 157–166, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Loechel, J. W. Fox, G. Murphy, R. Albrechtsen, and U. M. Wewer, “ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3,” Biochemical and Biophysical Research Communications, vol. 278, no. 3, pp. 511–515, 2000. View at Google Scholar
  21. C. K. Thodeti, C. Fröhlich, C. K. Nielsen et al., “ADAM12-mediated focal adhesion formation is differently regulated by β1 and β3 integrins,” FEBS Letters, vol. 579, no. 25, pp. 5589–5595, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. K. Iba, R. Albrechtsen, B. J. Gilpin, F. Loechel, and U. M. Wewer, “Cysteine-rich domain of human ADAM 12 (meltrin α) supports tumor cell adhesion,” American Journal of Pathology, vol. 154, no. 5, pp. 1489–1501, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Laigaard, T. Sørensen, C. Fröhlich et al., “ADAM12: a novel first-trimester maternal serum marker for Down syndrome,” Prenatal Diagnosis, vol. 23, no. 13, pp. 1086–1091, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus