Detection of Differentially Expressed MicroRNAs in Rheumatic Heart Disease: miR-1183 and miR-1299 as Potential Diagnostic Biomarkers

Figure 1

MicroRNA microarray expression data from plasma samples of rheumatic heart disease () and healthy control subjects (). (a) Heat map of microRNA microarray expression data from plasma samples of rheumatic heart disease () and healthy control subjects (). The expression of miRNA is hierarchically clustered on the -axis, and RHD plasma samples or healthy control plasma samples or healthy control plasma samples are hierarchically clustered on the -axis. The legend on the right indicates the miRNA represented in the corresponding row. The relative miRNA expression is depicted according to the color scale shown on the right. Red indicated upregulation; blue indicated downregulation; numbers 1, 2, and N1-3 indicate healthy control samples; numbers 3, 4, and 5 indicate RHD plasma samples. (b) Volcano plot from gene chips represents different fold changes from many upregulated miRNAs and downregulated miRNAs.

(a)

(b)