Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties

Figure 1

Neuronal survival and necrosis in the CA1 region of CO-exposed rates. The panels show representative H&E stained sections from control group (a), the CO exposure group (b), the SA + CO group (c), and the 20% mannitol + CO group (d). (a) The control rats, with rare neuronal death occurring in the CA1 region; (b) CO-exposed rats, with massive neuronal degeneration, apoptosis, or necrosis, and neuronal density decreased, as arrows indicated; (c) SA + CO group rats: neuronal density and cell morphology were well preserved; only mild degeneration of neuron could be observed occasionally; (d) 20% mannitol + CO exposure rats: severe damage of neuron was observed in CA1 region which was more serious than CO-exposed alone rats, as arrows indicated. All images were captured at 400x magnification; calibration bar, 100 μm.

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