Actions of Probiotics on Trinitrobenzenesulfonic Acid-Induced Colitis in Rats

Figure 4

Effects of tachykinergic and cholinergic inhibitors on EFS-induced contractions in isolated colonic preparations from rats. Representative tracings of mechanical responses in the absence and presence of blockers for tachykinin NK₁ receptors and tachykinin NK₂ receptors (L-732,132 and SR48968, 2 μM, resp.) and atropine, a blocker for muscarinic cholinoceptors (5 μM), in an intact rat (a), a TNBS-treated rat with the control diet at 14 days after TNBS treatment (b), and a TNBS-treated rat with the SF3B-containing diet at 14 days after TNBS treatment (c), are shown. Circles indicate the points of EFS. To simplify the interpretation of results of pharmacological experiments, blockers were applied under the condition in which the inhibitory components were eliminated by L-NAME (200 μM).

(a)

(b)

(c)