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BioMed Research International
Volume 2015, Article ID 530136, 6 pages
http://dx.doi.org/10.1155/2015/530136
Research Article

Management of Nonceliac Gluten Sensitivity by Gastroenterology Specialists: Data from an Italian Survey

1Center for The Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20100 Milan, Italy
2Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Via F. Sforza 35, 20100 Milan, Italy

Received 14 September 2015; Revised 26 October 2015; Accepted 4 November 2015

Academic Editor: Michael Mahler

Copyright © 2015 Federica Branchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Sapone, J. C. Bai, C. Ciacci et al., “Spectrum of gluten-related disorders: consensus on new nomenclature and classification,” BMC Medicine, vol. 10, article 13, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Catassi, J. C. Bai, B. Bonaz et al., “Non-celiac gluten sensitivity: the new frontier of gluten related disorders,” Nutrients, vol. 5, no. 10, pp. 3839–3853, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Catassi, L. Elli, B. Bonaz et al., “Diagnosis of non-celiac gluten sensitivity (NCGS): the Salerno Experts' Criteria,” Nutrients, vol. 7, no. 6, pp. 4966–4977, 2015. View at Google Scholar
  4. L. Elli, F. Branchi, C. Tomba et al., “Diagnosis of gluten related disorders: celiac disease, wheat allergy and non-celiac gluten sensitivity,” World Journal of Gastroenterology, vol. 21, no. 23, pp. 7110–7119, 2015. View at Publisher · View at Google Scholar
  5. J. F. Ludvigsson, D. A. Leffler, J. C. Bai et al., “The Oslo definitions for coeliac disease and related terms,” Gut, vol. 62, no. 1, pp. 43–52, 2013. View at Publisher · View at Google Scholar
  6. L. Elli, L. Roncoroni, and M. T. Bardella, “Non-celiac gluten sensitivity: time for sifting the grain,” World Journal of Gastroenterology, vol. 21, no. 27, pp. 8221–8226, 2015. View at Publisher · View at Google Scholar
  7. U. Volta, M. T. Bardella, A. Calabro, R. Troncone, G. R. Corazza, and The Study Group for Non-Celiac Gluten Sensitivity, “An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity,” BMC Medicine, vol. 12, article 85, 2014. View at Publisher · View at Google Scholar
  8. B. T. Cooper, G. K. T. Holmes, R. Ferguson, R. A. Thompson, R. N. Allan, and W. T. Cooke, “Gluten-sensitive diarrhea without evidence of celiac disease,” Gastroenterology, vol. 79, no. 5, pp. 801–806, 1980. View at Google Scholar · View at Scopus
  9. A. Ellis and B. D. Linaker, “Non-coeliac gluten sensitivity?” The Lancet, vol. 311, no. 8078, pp. 1358–1359, 1978. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Jonas, “Wheat-sensitive—but not coeliac,” The Lancet, vol. 2, p. 1047, 1978. View at Google Scholar
  11. A. Rubio-Tapia, J. F. Ludvigsson, T. L. Brantner, J. A. Murray, and J. E. Everhart, “The prevalence of celiac disease in the United States,” The American Journal of Gastroenterology, vol. 107, no. 10, pp. 1538–1544, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Tanpowpong, T. R. Ingham, P. K. Lampshire et al., “Coeliac disease and gluten avoidance in New Zealand children,” Archives of Disease in Childhood, vol. 97, no. 1, pp. 12–16, 2012. View at Publisher · View at Google Scholar
  13. I. Aziz, N. R. Lewis, M. Hadjivassiliou et al., “A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care,” European Journal of Gastroenterology & Hepatology, vol. 26, no. 1, pp. 33–39, 2014. View at Publisher · View at Google Scholar
  14. I. Aziz and D. S. Sanders, “Patients who avoid wheat and gluten: is that health or lifestyle?” Digestive Diseases and Sciences, vol. 59, no. 6, pp. 1080–1082, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Golley, N. Corsini, D. Topping, M. Morell, and P. Mohr, “Motivations for avoiding wheat consumption in Australia: results from a population survey,” Public Health Nutrition, vol. 18, no. 3, pp. 490–499, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Fasano, A. Sapone, V. Zevallos, and D. Schuppan, “Nonceliac gluten sensitivity,” Gastroenterology, vol. 148, no. 6, pp. 1195–1204, 2015. View at Publisher · View at Google Scholar
  17. T. A. Kabbani, R. R. Vanga, D. A. Leffler et al., “Celiac disease or non-celiac gluten sensitivity? an approach to clinical differential diagnosis,” American Journal of Gastroenterology, vol. 109, no. 5, pp. 741–746, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. E. F. Verdu, D. Armstrong, and J. A. Murray, “Between celiac disease and irritable bowel syndrome: the ‘no man's land’ of gluten sensitivity,” The American Journal of Gastroenterology, vol. 104, no. 6, pp. 1587–1594, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. U. Volta, G. Caio, F. Tovoli, and R. De Giorgio, “Non-celiac gluten sensitivity: questions still to be answered despite increasing awareness,” Cellular and Molecular Immunology, vol. 10, no. 5, pp. 383–392, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. J. R. Biesiekierski, S. L. Peters, E. D. Newnham, O. Rosella, J. G. Muir, and P. R. Gibson, “No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates,” Gastroenterology, vol. 145, no. 2, pp. 320–328, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Junker, S. Zeissig, S.-J. Kim et al., “Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4,” Journal of Experimental Medicine, vol. 209, no. 13, pp. 2395–2408, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Rubio-Tapia, I. D. Hill, C. P. Kelly, A. H. Calderwood, and J. A. Murray, “ACG clinical guidelines: diagnosis and management of celiac disease,” American Journal of Gastroenterology, vol. 108, no. 5, pp. 656–677, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Carroccio, P. Mansueto, G. Iacono et al., “Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity,” American Journal of Gastroenterology, vol. 107, no. 12, pp. 1898–1906, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Elli, “Where's the evidence for gluten sensitivity?” British Medical Journal, vol. 345, Article ID e7360, 2012. View at Publisher · View at Google Scholar
  25. A. Di Sabatino, P. Giuffrida, and G. R. Corazza, “Still waiting for a definition of nonceliac gluten sensitivity,” Journal of Clinical Gastroenterology, vol. 47, no. 7, pp. 567–569, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Nijeboer, H. J. Bontkes, C. J. J. Mulder, and G. Bouma, “Non-celiac gluten sensitivity. Is it in the gluten or the grain?” Journal of Gastrointestinal and Liver Diseases, vol. 22, no. 4, pp. 435–440, 2013. View at Google Scholar · View at Scopus
  27. R. Lyttleton, Lying Truths. A Critical Scrutiny of Current Beliefs and Conventions, Pergamon Press, Oxford, UK, 1979.
  28. A. Di Sabatino, U. Volta, C. Salvatore et al., “Small amounts of gluten in subjects with suspected nonceliac gluten sensitivity: a randomized, double-blind, placebo-controlled, cross-over trial,” Clinical Gastroenterology and Hepatology, vol. 13, no. 9, pp. 1604–1612.e3, 2015. View at Publisher · View at Google Scholar
  29. D. V. Digiacomo, C. A. Tennyson, P. H. Green, and R. T. Demmer, “Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA: results from the continuous national health and nutrition examination survey 2009–2010,” Scandinavian Journal of Gastroenterology, vol. 48, no. 8, pp. 921–925, 2013. View at Publisher · View at Google Scholar · View at Scopus