TY - JOUR A2 - Liao, Xiao-Bo AU - Zhao, Wang AU - Zhao, Shui-Ping AU - Zhao, Yu-Hong PY - 2015 DA - 2015/06/28 TI - MicroRNA-143/-145 in Cardiovascular Diseases SP - 531740 VL - 2015 AB - MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145. SN - 2314-6133 UR - https://doi.org/10.1155/2015/531740 DO - 10.1155/2015/531740 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -