MicroRNA-143/-145 in Cardiovascular Diseases

Figure 1

Roles of miR-143/-145 in the regulation of vascular smooth muscle cell differentiation and proliferation (adapted from Cordes et al. [31]). Expressions of miR-143/-145 are positively regulated by SRF with the functions to repress several factors, including KLF4 and Elk-1, which are reported to be involved in the regulation of smooth muscle cell proliferation, leading to promotion of smooth muscle cell differentiation and inhibition of proliferation. SRF: serum response factor; Myocd: myocardin; KLF4: Kruppel-like factor 4; Elk-1: Ets-like gene 1.