BioMed Research International / 2015 / Article / Tab 1

Research Article

ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes

Table 1

Secreted proteins of unstimulated and stimulated PBLs obtained from different subjects.

Parameter Unstimulated cells LPS-stimulated cells Range (2) = (RV(3) + LPS)/LPS(2) = (EPA(3) + LPS)/LPS
(pg/mL)(pg/mL)(pg/mL)

IL-1β0 ± 0(1)7889 ± 1250(1)2025–180002.62 ± 0.302.76 ± 0.94
IL-61 ± 1111644 ± 1951951300–2090001.76 ± 0.302.29 ± 0.51
IL-10 1 ± 11279 ± 230388–25301.29 ± 0.351.06 ± 0.21
IL-12 (p70)0 ± 014 ± 70–73
TNF-α0 ± 03499 ± 1300418–127500.86 ± 0.151.44 ± 0.65
CCL2/MCP-11 ± 1724 ± 163363–20650.77 ± 0.260.95 ± 0.14
CCL3/MIP-1α1 ± 114718 ± 26982720–282501.51 ± 0.561.27 ± 0.47
CCL4/MIP-1β182 ± 3168950 ± 1284433300–1625001.75 ± 0.460.81 ± 0.17
CCL5/RANTES 536 ± 1176013 ± 1978670–203001.55 ± 1.570.77 ± 0.14
CCL11/Eotaxin28 ± 8448 ± 8278–8781.16 ± 0.111.04 ± 0.09
CXCL8/IL-8311 ± 35298980 ± 50712108800–6140000.79 ± 0.352.10 ± 0.60
PGE2121 ± 153437 ± 4991680–62490.11 ± 0.172.10 ± 0.64

(1)Mean ± SEM of values obtained from PBLs of 8 different subjects (each done in duplicate).
(2)Ratio: (metabolites produced by PBLs treated with substance + LPS)/metabolites produced by PBLs treated with LPS. Mean ± SD of triplicate values obtained from PBLs of 4 different subjects.
(3)25 μmol/L RV, 20 μmol/L EPA.