Review Article
Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies
Table 6
Few examples of anti-IGF-RI monoclonal antibodies (MAbs) [
223].
| Monoclonal antibody | Class | Clinical information |
| CP-751,871 | Fully human IgG2 mab | Ewing’s sarcoma family of tumours, breast cancer, single agent in metastatic CRC |
| IMC-A12 | Fully human IgG1 mab | Ewing’s sarcoma family of tumours CRC and H&N cancer |
| R1507 | Fully human IgG1 mab previously known as RO4858696 | Pediatric patients and sarcomas. |
| AMG-479 | Fully human mab | Ewing’s sarcoma family of tumours, pancreatic cancer |
| SCH-717454 | Fully human mab previously known as 19D12 (Medarex) | Colorectal cancer (CRC) |
| AVE-1642 | Humanized mab | Previously known as EM164 (ImmunoGen) |
| MK-0646 | Fabre Humanized mab Previously known as A2CHM, F50035, 7C10, or 7H2HM | Colorectal cancer (CRC) |
| BIIB022 | Fully human nonglycosylated IgG4.P antibody | Devoid of Fc-effector function to eliminate potential Fc mediated toxicity to the normal vital organs. |
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