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BioMed Research International
Volume 2015, Article ID 539408, 10 pages
http://dx.doi.org/10.1155/2015/539408
Research Article

The Impact of LEP G-2548A and LEPR Gln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a Mexican Mestizo Population

1Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico
2Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Boulevard Marcelino García Barragán No. 1421, Esquina Calzada Olímpica, 44430 Guadalajara, JAL, Mexico
3UDG-CA-701, Grupo de Investigación Inmunometabolismo en Enfermedades Emergentes (GIIEE), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico
4Instituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico
5Servicio de Reumatología, División de Medicina Interna, Hospital Civil “Dr. Juan I. Menchaca”, Universidad de Guadalajara, Salvador de Quevedo y Zubieta No. 750, 44340 Guadalajara, JAL, Mexico
6HMIELM, Secretaria de Salud Jalisco, Avenida Constituyentes 1075, Colonia Moderna, 44190 Guadalajara, JAL, Mexico
7Instituto Tecnológico y de Estudios Superiores de Monterrey (ITESM), Campus Guadalajara, Avenida General Ramón Corona 2514, San Juan de Ocotán, 45201 Zapopan, JAL, Mexico

Received 29 December 2014; Accepted 23 April 2015

Academic Editor: Laura Guidetti

Copyright © 2015 Efraín Chavarria-Avila et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The polymorphisms in leptin (LEP G-2548A) and leptin-receptor (LEPR Gln223Arg) seem to influence obesity and lipid metabolism among others. The aim of this study was to investigate the effect of these polymorphisms on adiposity, leptin (sLeptin), and leptin-receptor (sLeptin-receptor) serum concentrations as well as inflammation markers. We included 382 adults originally from Western Mexico. They were genotyped by PCR-RFLP. Obese individuals showed higher sLeptin ( ng/mL) but lower sLeptin-receptor ( ng/mL) levels than normal weight ones ( ng/mL,  ng/mL, resp.), . Obese subjects carriers of Arg/Arg genotype had more () sLeptin-receptor ( ng/mL) and less () sLeptin ( ng/mL) levels than Gln/Gln genotype ( ng/mL,  ng/mL, resp.). Body fat mass was lower (P from 0.003 to 0.045) for A/A () or Arg/Arg () genotypes with respect to G/G () and G/A () or Gln/Gln () and Gln/Arg () genotypes carriers. Our results suggest that LEP -2548A and LEPR 223Arg could be genetic markers of less body fat mass accumulation in obese subjects from Western Mexico.