Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law

Figure 4

Contraction force: the spheroidal syncytia showed minimum contraction force at 200 mmHg (with statistically significant differences in comparison with the adjacent values at 100 and 300 mmHg []); the flat syncytia were characterized by maximum contraction force at 100 mmHg (with statistically significant differences in comparison with the adjacent values at 0 and 200 mmHg []). At all pressures, the contraction force of spheroidal syncytia was significantly higher than the contraction force of flat syncytia ().