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BioMed Research International
Volume 2015, Article ID 542502, 19 pages
Review Article

PRP and Articular Cartilage: A Clinical Update

1Department of Orthopaedics and Traumatology, University of Torino, 10100 Torino, Italy
2Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
3Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy
4IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy

Received 25 August 2014; Revised 20 October 2014; Accepted 6 November 2014

Academic Editor: Giuseppe Filardo

Copyright © 2015 Antonio Marmotti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The convincing background of the recent studies, investigating the different potentials of platelet-rich plasma, offers the clinician an appealing alternative for the treatment of cartilage lesions and osteoarthritis. Recent evidences in literature have shown that PRP may be helpful both as an adjuvant for surgical treatment of cartilage defects and as a therapeutic tool by intra-articular injection in patients affected by osteoarthritis. In this review, the authors introduce the trophic and anti-inflammatory properties of PRP and the different products of the available platelet concentrates. Then, in a complex scenario made of a great number of clinical variables, they resume the current literature on the PRP applications in cartilage surgery as well as the use of intra-articular PRP injections for the conservative treatment of cartilage degenerative lesions and osteoarthritis in humans, available as both case series and comparative studies. The result of this review confirms the fascinating biological role of PRP, although many aspects yet remain to be clarified and the use of PRP in a clinical setting has to be considered still exploratory.