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BioMed Research International
Volume 2015, Article ID 561242, 9 pages
http://dx.doi.org/10.1155/2015/561242
Review Article

Current Advances in the Application of Raman Spectroscopy for Molecular Diagnosis of Cervical Cancer

1DIT Centre for Radiation and Environmental Science, Focas Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
2School of Physics, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
3School of Biological Sciences, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland

Received 12 September 2014; Revised 22 December 2014; Accepted 27 December 2014

Academic Editor: Massimo Origoni

Copyright © 2015 Inês Raquel Martins Ramos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Raman spectroscopy provides a unique biochemical fingerprint capable of identifying and characterizing the structure of molecules, cells, and tissues. In cervical cancer, it is acknowledged as a promising biochemical tool due to its ability to detect premalignancy and early malignancy stages. This review summarizes the key research in the area and the evidence compiled is very encouraging for ongoing and further research. In addition to the diagnostic potential, promising results for HPV detection and monitoring treatment response suggest more than just a diagnosis prospective. A greater body of evidence is however necessary before Raman spectroscopy is fully validated for clinical use and larger comprehensive studies are required to fully establish the role of Raman spectroscopy in the molecular diagnostics of cervical cancer.