Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 563247, 11 pages
http://dx.doi.org/10.1155/2015/563247
Research Article

Vitamin E Supplementation Delays Cellular Senescence In Vitro

DSM Nutritional Products Ltd., R & D Human Nutrition and Health, P.O. Box 2676, 4002 Basel, Switzerland

Received 31 July 2015; Accepted 8 October 2015

Academic Editor: Paul J. Higgins

Copyright © 2015 Giorgio La Fata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Q. M. Chen, “Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints,” Annals of the New York Academy of Sciences, vol. 908, pp. 111–125, 2000. View at Google Scholar · View at Scopus
  2. C. López-Otín, M. A. Blasco, L. Partridge, M. Serrano, and G. Kroemer, “The hallmarks of aging,” Cell, vol. 153, no. 6, pp. 1194–1217, 2013. View at Publisher · View at Google Scholar
  3. S. Makpol, A. Zainuddin, K. H. Chua, Y. A. Mohd Yusof, and W. Z. W. Ngah, “Gamma-tocotrienol modulated gene expression in senescent human diploid fibroblasts as revealed by microarray analysis,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 454328, 11 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Wagner, B. Hampel, D. Bernhard, M. Hala, W. Zwerschke, and P. Jansen-Dürr, “Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis,” Experimental Gerontology, vol. 36, no. 8, pp. 1327–1347, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Hayflick and P. S. Moorhead, “The serial cultivation of human diploid cell strains,” Experimental Cell Research, vol. 25, no. 3, pp. 585–621, 1961. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Lawless, C. Wang, D. Jurk, A. Merz, T. V. Zglinicki, and J. F. Passos, “Quantitative assessment of markers for cell senescence,” Experimental Gerontology, vol. 45, no. 10, pp. 772–778, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. R. Smith and D. W. Lincoln II, “Aging of cells in culture,” International Review of Cytology, vol. 89, pp. 151–177, 1984. View at Google Scholar
  8. S. Goldstein, “Replicative senescence: the human fibroblast comes of age,” Science, vol. 249, no. 4973, pp. 1129–1133, 1990. View at Publisher · View at Google Scholar · View at Scopus
  9. G. P. Dimri, X. Lee, G. Basile et al., “A biomarker that identifies senescent human cells in culture and in aging skin in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 20, pp. 9363–9367, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Liu, H. Liu, Y. Ha, R. G. Tilton, and W. Zhang, “Oxidative stress induces endothelial cell senescence via downregulation of Sirt6,” BioMed Research International, vol. 2014, Article ID 902842, 13 pages, 2014. View at Publisher · View at Google Scholar
  11. J.-M. Zingg, “Modulation of signal transduction by vitamin E,” Molecular Aspects of Medicine, vol. 28, no. 5-6, pp. 481–506, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. G. La Fata, P. Weber, and M. H. Mohajeri, “Effects of vitamin E on cognitive performance during ageing and in Alzheimer’s disease,” Nutrients, vol. 6, no. 12, pp. 5453–5472, 2014. View at Publisher · View at Google Scholar
  13. A. La Rue, K. M. Koehler, S. J. Wayne, S. J. Chiulli, K. Y. Haaland, and P. J. Garry, “Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment,” The American Journal of Clinical Nutrition, vol. 65, no. 1, pp. 20–29, 1997. View at Google Scholar · View at Scopus
  14. F. Grodstein, J. Chen, and W. C. Willett, “High-dose antioxidant supplements and cognitive function in community-dwelling elderly women,” The American Journal of Clinical Nutrition, vol. 77, no. 4, pp. 975–984, 2003. View at Google Scholar · View at Scopus
  15. T. Scholzen and J. Gerdes, “The Ki-67 protein: from the known and the unknown,” Journal of Cellular Physiology, vol. 182, no. 3, pp. 311–322, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Salic and T. J. Mitchison, “A chemical method for fast and sensitive detection of DNA synthesis in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 7, pp. 2415–2420, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Hara, R. Smith, D. Parry, H. Tahara, S. Stone, and G. Peters, “Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence,” Molecular and Cellular Biology, vol. 16, no. 3, pp. 859–867, 1996. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Wong and K. Riabowol, “Differential CDK-inhibitor gene expression in aging human diploid fibroblasts,” Experimental Gerontology, vol. 31, no. 1-2, pp. 311–325, 1996. View at Publisher · View at Google Scholar · View at Scopus
  19. D. A. Alcorta, Y. Xiong, D. Phelps, G. Hannon, D. Beach, and J. C. Barrett, “Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 24, pp. 13742–13747, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Campisi and F. D. Di Fagagna, “Cellular senescence: when bad things happen to good cells,” Nature Reviews Molecular Cell Biology, vol. 8, no. 9, pp. 729–740, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. A. R. Tomé, D. Feng, and R. M. Freitas, “The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures,” Neurochemical Research, vol. 35, no. 4, pp. 580–587, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Tanaka, Y. Moritoh, and N. Miwa, “Age-dependent telomere-shortening is repressed by phosphorylated alpha-tocopherol together with cellular longevity and intracellular oxidative-stress reduction in human brain microvascular endotheliocytes,” Journal of Cellular Biochemistry, vol. 102, no. 3, pp. 689–703, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Makpol, A. Zainuddin, N. A. Rahim, Y. A. M. Yusof, and W. Z. W. Ngah, “Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals,” Planta Medica, vol. 76, no. 9, pp. 869–875, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. E. Yegorov, S. S. Akimov, R. Hass, A. V. Zelenin, and I. A. Prudovsky, “Endogenous β-galactosidase activity in continuously nonproliferating cells,” Experimental Cell Research, vol. 243, no. 1, pp. 207–211, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Severino, R. G. Allen, S. Balin, A. Balin, and V. J. Cristofalo, “Is beta-galactosidase staining a marker of senescence in vitro and in vivo?” Experimental Cell Research, vol. 257, no. 1, pp. 162–171, 2000. View at Publisher · View at Google Scholar · View at Scopus
  26. N.-C. Yang and M.-L. Hu, “The limitations and validities of senescence associated-β-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells,” Experimental Gerontology, vol. 40, no. 10, pp. 813–819, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. G. H. Stein and V. Dulić, “Origins of G1 arrest in senescent human fibroblasts,” BioEssays, vol. 17, no. 6, pp. 537–543, 1995. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Johnson, D. Dimitrov, P. J. Vojta et al., “Evidence for a p53-independent pathway for upregulation of SDI1/CIP1/WAF1/p21 RNA in human cells,” Molecular Carcinogenesis, vol. 11, no. 2, pp. 59–64, 1994. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Maciag, G. A. Hoover, M. B. Stemerman, and R. Weinstein, “Serial propagation of human endothelial cells in vitro,” Journal of Cell Biology, vol. 91, no. 2, part 1, pp. 420–426, 1981. View at Publisher · View at Google Scholar · View at Scopus
  30. B. van der Loo, M. J. Fenton, and J. D. Erusalimsky, “Cytochemical detection of a senescence-associated β-galactosidase in endothelial and smooth muscle cells from human and rabbit blood vessels,” Experimental Cell Research, vol. 241, no. 2, pp. 309–315, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. R. M. Ortega, A. M. Requejo, A. M. López-Sobaler et al., “Cognitive function in elderly people is influenced by vitamin E status,” Journal of Nutrition, vol. 132, no. 7, pp. 2065–2068, 2002. View at Google Scholar · View at Scopus
  32. B. Kłapcińska, J. Derejczyk, K. Wieczorowska-Tobis, A. Sobczak, E. Sadowska-Krepa, and A. Danch, “Antioxidant defense in centenarians (a preliminary study),” Acta Biochimica Polonica, vol. 47, no. 2, pp. 281–292, 2000. View at Google Scholar
  33. M. W. Dysken, M. Sano, S. Asthana et al., “Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial,” The Journal of the American Medical Association, vol. 311, no. 1, pp. 33–44, 2014. View at Google Scholar
  34. M. Sano, C. Ernesto, R. G. Thomas et al., “A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease,” The New England Journal of Medicine, vol. 336, no. 17, pp. 1216–1222, 1997. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Makpol, L. W. Durani, K. H. Chua, Y. A. Mohd Yusof, and W. Z. Wan Ngah, “Tocotrienol-rich fraction prevents cell cycle arrest and elongates telomere length in senescent human diploid fibroblasts,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 506171, 11 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. X. Qun, C. G. Parks, L. A. DeRoo, R. M. Cawthon, D. P. Sandler, and H. Chen, “Multivitamin use and telomere length in women,” The American Journal of Clinical Nutrition, vol. 89, no. 6, pp. 1857–1863, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Monaghan and M. F. Haussmann, “Do telomere dynamics link lifestyle and lifespan?” Trends in Ecology and Evolution, vol. 21, no. 1, pp. 47–53, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Banks, J. R. Speakman, and C. Selman, “Vitamin E supplementation and mammalian lifespan,” Molecular Nutrition and Food Research, vol. 54, no. 5, pp. 719–725, 2010. View at Publisher · View at Google Scholar · View at Scopus