Protective and Curative Effects of the Sea Cucumber Holothuria atra Extract against DMBA-Induced Hepatorenal Diseases in Rats

Table 2

Modulatory influence of Holothuria atra extract (HaE) on gamma glutamyl transferase (GGT) activity and total protein content of 7,12-dimethylbenz[a]anthracene (DMBA) treated rats.

Treatment	Groups		GGT; (U/L)	Total protein; (mg/dL)
Pretreatment	Control		2.54 ± 0.67^a	17.54 ± 0.45^d
	7 days	DMBA	5.21 ± 0.81^de	12.59 ± 0.74^bc
		HaE	2.08 ± 0.43^abc	12.12 ± 0.19^b
	14 days	DMBA	60.16 ± 17.90^e	14.616 ± 0.59^c
		HaE	16.90 ± 6.52^ab	9.96 ± 0.36^a
Posttreatment	Control		2.48 ± 0.63^a	16.86 ± 0.57^d
	7 days	DMBA	7.64 ± 2.68^de	12.51 ± 1.01^bc
		HaE	3.24 ± 0.29^abc	12.79 ± 0.28^bc
	14 days	DMBA	67.39 ± 21.26^e	12.85 ± 0.18^bc
		HaE	44.60 ± 15.53^ab	9.42 ± 1.40^a

Values are given as mean ± SEM for 6 rats in each group.
Each value not sharing a common letter superscript is significantly different ().