Protective and Curative Effects of the Sea Cucumber Holothuria atra Extract against DMBA-Induced Hepatorenal Diseases in Rats

Table 5

Modulatory influence of Holothuria atra extract (HaE) on some liver antioxidant enzymes activities of 7,12-dimethylbenz[a]anthracene (DMBA) treated rats.

Treatment	Groups		GST; (nmol/min/g tissue)	SOD; (U/g tissue)	CAT; (U/min)
Pretreatment	Control		2.70 ± 0.49^a	264.08 ± 28.23^d	686.40 ± 73.64^d
	7 days	DMBA	1.51 ± 0.18^b	201.53 ± 13.72^b	473.6 ± 55.50^ab
		HaE	1.45 ± 0.08^b	183.21 ± 9.71^ab	448.00 ± 14.96^ab
	14 days	DMBA	1.13 ± 0.16^b	168.32 ± 2.48^ab	362.40 ± 41.83^a
		HaE	2.18 ± 0.24^a	214.53 ± 6.87^c	560.00 ± 65.72^bc
Posttreatment	Control		2.68 ± 0.49^a	268.14 ± 28.84^d	683.40 ± 73.68^d
	7 days	DMBA	1.63 ± 0.24^b	166.39 ± 12.81^ab	472.00 ± 32.00^ab
		HaE	1.54 ± 0.10^b	164.14 ± 11.81^ab	552.00 ± 38.78^bc
	14 days	DMBA	1.20 ± 0.13^b	146.14 ± 7.96^a	440.00 ± 17.88^ab
		HaE	2.21 ± 0.10^a	220.10 ± 2.87^c	584.00 ± 29.93^c

Values are given as mean ± SEM for 6 rats in each group.
Each value not sharing a common letter superscript is significantly different ().