BioMed Research International / 2015 / Article / Tab 2

Review Article

Influence of Two Common Polymorphisms in the EPHX1 Gene on Warfarin Maintenance Dosage: A Meta-Analysis

Table 2

Meta-analysis of the associations between EPHX1 rs2292566 G>A polymorphism and warfarin maintenance dosage.

GG versus AAGG versus GAGA versus AA
SMD95% CISMD95% CISMD95% CI

Overall0.760.47~1.05<0.0010.6990.0%0.430.03~0.830.035<0.00187.6%0.31−0.15~0.760.1860.10547.7%
Ethnicity
 Caucasians0.520.07~1.030.0060.7160.0%0.280.07~0.490.0090.5500.0%0.40−0.25~1.060.2260.02872.0%
 Asians0.84−0.13~1.150.6990.8950.0%0.54−0.14~1.230.122<0.00192.6%0.05−0.72~0.820.8980.8300.0%
Sample size
 Small ()0.71−0.01~1.100.3100.4620.0%0.24−0.13~0.600.2100.05864.8%−0.05−0.46~0.360.8150.7240.0%
 Large ()0.820.40~1.24<0.0010.4790.0%0.670.01~1.340.042<0.00193.0%0.620.17~1.070.0070.3348.7%
Genotyping method
 TaqMan assay0.780.02~1.030.4650.7160.0%0.280.07~0.490.0090.55092.6%0.40−0.25~1.060.2260.02872.0%
 Non-TaqMan assay0.840.00~1.150.0510.8950.0%0.54−0.14~1.230.122<0.0010.0%0.05−0.72~0.820.8980.8300.0%

EPHX1: epoxide hydrolase 1; SMD: standardized mean difference; 95% CI: 95% confidence interval; : the value for the heterogeneity test.