[Retracted] Influence of Two Common Polymorphisms in the EPHX1 Gene on Warfarin Maintenance Dosage: A Meta-Analysis

Table 2

Meta-analysis of the associations between EPHX1 rs2292566 G>A polymorphism and warfarin maintenance dosage.

	GG versus AA					GG versus GA					GA versus AA
	SMD	95% CI				SMD	95% CI				SMD	95% CI
Overall	0.76	0.47~1.05	<0.001	0.699	0.0%	0.43	0.03~0.83	0.035	<0.001	87.6%	0.31	−0.15~0.76	0.186	0.105	47.7%
Ethnicity
Caucasians	0.52	0.07~1.03	0.006	0.716	0.0%	0.28	0.07~0.49	0.009	0.550	0.0%	0.40	−0.25~1.06	0.226	0.028	72.0%
Asians	0.84	−0.13~1.15	0.699	0.895	0.0%	0.54	−0.14~1.23	0.122	<0.001	92.6%	0.05	−0.72~0.82	0.898	0.830	0.0%
Sample size
Small ()	0.71	−0.01~1.10	0.310	0.462	0.0%	0.24	−0.13~0.60	0.210	0.058	64.8%	−0.05	−0.46~0.36	0.815	0.724	0.0%
Large ()	0.82	0.40~1.24	<0.001	0.479	0.0%	0.67	0.01~1.34	0.042	<0.001	93.0%	0.62	0.17~1.07	0.007	0.334	8.7%
Genotyping method
TaqMan assay	0.78	0.02~1.03	0.465	0.716	0.0%	0.28	0.07~0.49	0.009	0.550	92.6%	0.40	−0.25~1.06	0.226	0.028	72.0%
Non-TaqMan assay	0.84	0.00~1.15	0.051	0.895	0.0%	0.54	−0.14~1.23	0.122	<0.001	0.0%	0.05	−0.72~0.82	0.898	0.830	0.0%

EPHX1: epoxide hydrolase 1; SMD: standardized mean difference; 95% CI: 95% confidence interval; : the value for the heterogeneity test.