Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon-γ Signaling

Figure 2

IFN-γ reduces wild-type H. pylori virulence factor expressions. Wild-type and Δomp18 H. pylori were cultured to OD₆₀₀ ≈ 0.8 and then exposed or not to IFN-γ (50 pg/mL) for 6 h. Western blot and qRT-PCR analysis of protein (A) and mRNA (B) levels of CagA (a) and NapA (b). Quantitative RT-PCR data were standardized to that of 16s rRNA. Data are means ± SEM from 3 independent experiments. , .

(a)

(b)