Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon-γ Signaling
Omp18 is involved in H. pylori survival with NO oxidative stress and in macrophages. (a) Survival of wild-type and Δomp18 H. pylori with exposure to NO oxidative stress (simulation with sodium nitroprusside, SNP). CFU: colony formation unit. (b) Survival of wild-type and Δomp18 H. pylori in macrophages. Data are means ± SEM from 3 independent experiments. (c) SNP treatment for 6 h induces coccoid transformation and death of Δomp18 bacteria, and Δomp18 H. pylori without SNP treatment was a negative control. Confocal microscopy of cells stained with membrane-permeant SYTO-9 (green) and membrane-impermeant PI (red). Data are representative of 3 independent experiments. , .
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