TY - JOUR
A2 - Decristoforo, Clemens
AU - Lundblad, Henrik
AU - Maguire, Gerald Q.
AU - Karlsson-Thur, Charlotte
AU - Jonsson, Cathrine
AU - Noz, Marilyn E.
AU - Zeleznik, Michael P.
AU - Jacobsson, Hans
AU - Weidenhielm, Lars
PY - 2015
DA - 2015/09/07
TI - Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences
SP - 574705
VL - 2015
AB - Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consent to undergo Na18F− PET/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curve eliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions were compared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal) bone, and muscle. The SUVm(t) (m=max, mean) and a series of slopes were computed as (SUVm(ti)-SUVm(tj))/(ti-tj), for pairs of time values ti and tj. A Patlak-like analysis was performed for the same time values by computing ((VOIp(ti)/VOIe(ti))-(VOIp(tj)/VOIe(tj)))/(ti-tj), where p = broken bone, other bone, and muscle and e = expected activity in a VOI. Paired comparisons between Patlak-like and SUVm slopes showed good agreement by both linear regression and correlation coefficient analysis (r=84%,rs=78%-SUVmax,r=92%, and rs=91%-SUVmean), suggesting static scans could substitute for dynamic studies. Patlak-like slope differences of 0.1 min−1 or greater between examinations and SUVmax differences of ~5 usually indicated good remodeling progress, while negative Patlak-like slope differences of −0.06 min−1 usually indicated poor remodeling progress in this cohort.
SN - 2314-6133
UR - https://doi.org/10.1155/2015/574705
DO - 10.1155/2015/574705
JF - BioMed Research International
PB - Hindawi Publishing Corporation
KW -
ER -