TY - JOUR A2 - Decristoforo, Clemens AU - Lundblad, Henrik AU - Maguire, Gerald Q. AU - Karlsson-Thur, Charlotte AU - Jonsson, Cathrine AU - Noz, Marilyn E. AU - Zeleznik, Michael P. AU - Jacobsson, Hans AU - Weidenhielm, Lars PY - 2015 DA - 2015/09/07 TI - Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences SP - 574705 VL - 2015 AB - Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consent to undergo Na18F PET/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curve eliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions were compared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal) bone, and muscle. The SUVm(t) (m=max, mean) and a series of slopes were computed as (SUVm(ti)-SUVm(tj))/(ti-tj), for pairs of time values ti and tj. A Patlak-like analysis was performed for the same time values by computing ((VOIp(ti)/VOIe(ti))-(VOIp(tj)/VOIe(tj)))/(ti-tj), where p = broken bone, other bone, and muscle and e = expected activity in a VOI. Paired comparisons between Patlak-like and SUVm slopes showed good agreement by both linear regression and correlation coefficient analysis (r=84%,rs=78%-SUVmax,r=92%, and rs=91%-SUVmean), suggesting static scans could substitute for dynamic studies. Patlak-like slope differences of 0.1 min−1 or greater between examinations and SUVmax differences of ~5 usually indicated good remodeling progress, while negative Patlak-like slope differences of −0.06 min−1 usually indicated poor remodeling progress in this cohort. SN - 2314-6133 UR - https://doi.org/10.1155/2015/574705 DO - 10.1155/2015/574705 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -