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BioMed Research International
Volume 2015, Article ID 574705, 11 pages
http://dx.doi.org/10.1155/2015/574705
Clinical Study

Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences

1Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden
2School of Information and Communication Technology, KTH Royal Institute of Technology, 16440 Stockholm, Sweden
3Department of Hospital Physics, Karolinska University Hospital Solna, 17176 Stockholm, Sweden
4Department of Radiology, New York University, New York, NY 10016, USA
5School of Computing, College of Engineering, University of Utah, Salt Lake City, UT 84109, USA

Received 27 April 2015; Accepted 23 August 2015

Academic Editor: Clemens Decristoforo

Copyright © 2015 Henrik Lundblad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consent to undergo Na18F PET/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curve eliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions were compared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal) bone, and muscle. The (, mean) and a series of slopes were computed as , for pairs of time values and . A Patlak-like analysis was performed for the same time values by computing , where p = broken bone, other bone, and muscle and e = expected activity in a VOI. Paired comparisons between Patlak-like and slopes showed good agreement by both linear regression and correlation coefficient analysis (, and ), suggesting static scans could substitute for dynamic studies. Patlak-like slope differences of 0.1 min−1 or greater between examinations and differences of ~5 usually indicated good remodeling progress, while negative Patlak-like slope differences of −0.06 min−1 usually indicated poor remodeling progress in this cohort.